# Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111753](https://www.wikidata.org/wiki/Q21111753)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/MTHFD1)  
**Source**: https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P11586)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11586)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11586)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11586&geneProductId=UniProtKB:P11586)
7. [Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11586&geneProductId=UniProtKB:P11586)
8. [Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11586)
9. [Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11586)
10. [Expression of active domains of a human folate-dependent trifunctional enzyme in Escherichia coli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11586)
11. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11586&geneProductId=UniProtKB:P11586)
12. [Purification and characterization of a mitochondrial isozyme of C1-tetrahydrofolate synthase from Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11586&geneProductId=UniProtKB:P11586)
13. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11586&geneProductId=UniProtKB:P11586)
14. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11586&geneProductId=UniProtKB:P11586)
15. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11586&geneProductId=UniProtKB:P11586)
16. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11586&geneProductId=UniProtKB:P11586)
17. [Purification and characterization of a mitochondrial isozyme of C1-tetrahydrofolate synthase from Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11586)
18. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11586)
19. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11586)
20. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11586)
21. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11586)
22. [Characterization and review of MTHFD1 deficiency: four new patients, cellular delineation and response to folic and folinic acid treatment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11586)
23. Ensembl Release 99