# Metallothionein 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21118811](https://www.wikidata.org/wiki/Q21118811)  
**Source**: https://4ort.xyz/entity/metallothionein-3-q21118811


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P25713)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
5. [Effect of α-domain substitution on the structure, property and function of human neuronal growth inhibitory factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
6. [Redox activity of α-synuclein–Cu is silenced by Zn7-metallothionein-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
7. [Reaction of human metallothionein-3 with cisplatin and transplatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
8. [Metallothionein-III induces HIF-1α-mediated VEGF expression in brain endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25713&geneProductId=UniProtKB:P25713)
10. [The Unique N-Terminal Sequence of Metallothionein-3 Is Required to Regulate the Choice between Apoptotic or Necrotic Cell Death of Human Proximal Tubule Cells Exposed to Cd+2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
11. [Protective effect of metallothionein-III on DNA damage in response to reactive oxygen species](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
12. [Genome-wide YFP Fluorescence Complementation Screen Identifies New Regulators for Telomere Signaling in Human Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
13. [Human metallothioneins 2 and 3 differentially affect amyloid‐beta binding by transthyretin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
14. [The functional significance of brain metallothioneins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
15. [The effect of nitric oxide on metal release from metallothionein-3: gradual unfolding of the protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
16. [The role of Thr5 in human neuron growth inhibitory factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
18. [Expression of MT-3 protein in the human kidney](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25713&geneProductId=UniProtKB:P25713)
19. [Location-Specific Epigenetic Regulation of the Metallothionein 3 Gene in Esophageal Adenocarcinomas](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25713&geneProductId=UniProtKB:P25713)
20. [Association of Metallothionein-III with Oligodendroglial Cytoplasmic Inclusions in Multiple System Atrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
21. [Expression of MT-3 protein in the human kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
22. [Expression of Metallothionein Isoform 3 (MT-3) Determines the Choice between Apoptotic or Necrotic Cell Death in Cd+2-Exposed Human Proximal Tubule Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
23. [Expression of metallothionein-III induced by hypoxia attenuates hypoxia-induced cell death in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
24. [Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
25. [Location-Specific Epigenetic Regulation of the Metallothionein 3 Gene in Esophageal Adenocarcinomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
26. [The Unique N-Terminal Sequence of Metallothionein-3 Is Required to Regulate the Choice between Apoptotic or Necrotic Cell Death of Human Proximal Tubule Cells Exposed to Cd+2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25713&geneProductId=UniProtKB:P25713)
27. [Mutation at Glu23 eliminates the neuron growth inhibitory activity of human metallothionein-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
28. [Metallothionein-III induces HIF-1α-mediated VEGF expression in brain endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25713&geneProductId=UniProtKB:P25713)
29. [The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
30. [PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25713)
31. Ensembl Release 99
32. UMLS 2023