# MET proto-oncogene, receptor tyrosine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5005897](https://www.wikidata.org/wiki/Q5005897)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Hepatocyte_growth_factor_receptor)  
**Source**: https://4ort.xyz/entity/met-proto-oncogene-receptor-tyrosine-kinase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2103882)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545365)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2103851)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL460702)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3188267)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3039525)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1822792)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1236107)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3402762)
12. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL496102)
13. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08581)
14. Q20641742
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
16. [Cross-talk between the proto-oncogenes Met and Ron](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08581&geneProductId=UniProtKB:P08581)
17. [Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
18. [Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
19. [Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
20. [Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
21. [Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
22. [Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
23. [Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
24. [Large-scale structural analysis of the classical human protein tyrosine phosphatome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
25. [Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
26. [Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
27. [Oligomerization-induced differential dephosphorylation of c-Met receptor tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
28. [Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
29. [EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
30. [Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
31. [hTID-1 defines a novel regulator of c-Met Receptor signaling in renal cell carcinomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
32. [Structural basis for agonism and antagonism of hepatocyte growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
33. [VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
34. [EGFR/Met association regulates EGFR TKI resistance in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
35. [An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
36. [Interplay between scatter factor receptors and B plexins controls invasive growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
37. [Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
38. [Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
39. [Effect of cancer-associated mutations in the PlexinB1 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
40. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
41. [EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
42. [Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
43. [Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
44. [Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
45. [Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
46. [Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
47. [A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
48. [Structural basis of hepatocyte growth factor/scatter factor and MET signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
49. [Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581)
50. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08581&geneProductId=UniProtKB:P08581)