# Membrane metalloendopeptidase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q414232](https://www.wikidata.org/wiki/Q414232)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Neprilysin)  
**Source**: https://4ort.xyz/entity/membrane-metalloendopeptidase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08473)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
6. [HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
7. [Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
8. [Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
10. [Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126)](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473)
11. [Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473)
12. [Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473)
13. [Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473)
14. [Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
15. [Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
16. [Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
17. [Localization of mature neprilysin in lipid rafts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
18. [Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
19. [Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
20. [A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
21. [Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
22. [Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
23. [Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
24. [Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
25. [CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
26. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473)
27. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473)
28. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473)
29. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473)
30. [Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
31. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473)
32. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
33. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
34. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
35. [CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473)
36. [Genetic and functional effects of membrane metalloendopeptidase on diabetic nephropathy development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
37. [Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473)
38. [Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
39. [Neprylisin decreases uniformly in Alzheimer's disease and in normal aging](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
40. [Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473)
41. Ensembl Release 99
42. Identifiers.org
43. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)