# MEFV innate immuity regulator, pyrin

> mammalian protein found in Homo sapiens

**Wikidata**: [Q11681842](https://www.wikidata.org/wiki/Q11681842)  
**Source**: https://4ort.xyz/entity/mefv-innate-immuity-regulator-pyrin


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O15553)
3. Q20641742
4. [Alternative splicing at the MEFV locus involved in familial Mediterranean fever regulates translocation of the marenostrin/pyrin protein to the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
6. [TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
7. [TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
8. [Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
9. [Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
10. [Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
11. [The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553)
13. [The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553)
14. [TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
15. [The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
17. [TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553)
18. [AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
19. [Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
20. [Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553)
21. Ensembl Release 99