# Mediator complex subunit 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21985771](https://www.wikidata.org/wiki/Q21985771)  
**Source**: https://4ort.xyz/entity/mediator-complex-subunit-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q925J9)
3. Q20641742
4. [Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q925J9&geneProductId=UniProtKB:Q925J9)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
6. [Defects of the Heart, Eye, and Megakaryocytes in Peroxisome Proliferator Activator Receptor-binding Protein (PBP) Null Embryos Implicate GATA Family of Transcription Factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q925J9&geneProductId=UniProtKB:Q925J9)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
9. [Mediator and cohesin connect gene expression and chromatin architecture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
10. [Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
11. [Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
12. [The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
13. [Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
14. [A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
15. [The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
16. [Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
17. [Dominant and redundant functions of TFIID involved in the regulation of hepatic genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
18. [Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
19. [Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
20. [Differential Expression of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Its Coactivators Steroid Receptor Coactivator-1 and PPAR-Binding Protein PBP in the Brown Fat, Urinary Bladder, Colon, and Breast of the Mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
21. [Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
22. [Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
23. [Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q925J9&geneProductId=UniProtKB:Q925J9)
24. [Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
25. [A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q925J9&geneProductId=UniProtKB:Q925J9)
26. [ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q925J9&geneProductId=UniProtKB:Q925J9)
27. [The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q925J9&geneProductId=UniProtKB:Q925J9)
28. [Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q925J9&geneProductId=UniProtKB:Q925J9)
29. [A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
30. [The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
31. [The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
32. [The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
33. [Peroxisome proliferator-activated receptor-binding protein null mutation results in defective mammary gland development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
34. [Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
35. [Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
36. [Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q925J9&geneProductId=UniProtKB:Q925J9)
37. [Differential Expression of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Its Coactivators Steroid Receptor Coactivator-1 and PPAR-Binding Protein PBP in the Brown Fat, Urinary Bladder, Colon, and Breast of the Mouse](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q925J9&geneProductId=UniProtKB:Q925J9)
38. [Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q925J9&geneProductId=UniProtKB:Q925J9)
39. [Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q925J9&geneProductId=UniProtKB:Q925J9)
40. [Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
41. [Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
42. [Role of type I IFNs in pulmonary complications of Pneumocystis murina infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
43. [The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
44. [The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
45. [Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
46. [Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925J9)
47. ensembl Release 106