# Mediator complex subunit 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173409](https://www.wikidata.org/wiki/Q21173409)  
**Source**: https://4ort.xyz/entity/mediator-complex-subunit-1-q21173409


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q15648)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
6. [The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
7. [MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
8. [The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
9. [A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648)
10. [The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648)
11. [Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648)
12. [The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
13. [The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
14. [MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
15. [CCAR1/CoCoA pair‐mediated recruitment of the Mediator defines a novel pathway for GATA1 function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
16. [The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
17. [Enhancer activation requires trans-recruitment of a mega transcription factor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
18. [Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
19. [The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
20. [Subunit architecture and functional modular rearrangements of the transcriptional mediator complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
21. [Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648)
22. [Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648)
23. [Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
24. [Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
25. [Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
26. [Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
27. [Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
28. [A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
29. [Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
31. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648)
32. [Composite co-activator ARC mediates chromatin-directed transcriptional activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
33. [MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648)
34. [Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648)
35. [A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648)
36. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
37. [A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
38. [Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
39. [The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648)
40. [MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648)
41. Ensembl Release 99
42. UMLS 2023