# mechanistic target of rapamycin kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q285613](https://www.wikidata.org/wiki/Q285613)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/MTOR)  
**Source**: https://4ort.xyz/entity/mechanistic-target-of-rapamycin-kinase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL75880)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2103839)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1922094)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1801204)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL571209)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545097)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1236962)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2336325)
11. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P42345)
12. Q20641742
13. Freebase Data Dumps. 2013
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
15. [mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
16. [Characterization of ubiquilin 1, an mTOR-interacting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
17. [Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
18. [Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345)
20. [GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345)
21. [Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345)
22. [mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345)
23. [PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
24. [Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
25. [CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
26. [DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
27. [5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
28. [PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
29. [mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
30. [The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
31. [HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
32. [Phospholipase D1 is an effector of Rheb in the mTOR pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
33. [Visualization of biochemical networks in living cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
34. [Architecture of human mTOR complex 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
35. [Huntingtin functions as a scaffold for selective macroautophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
36. [A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
37. [The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
38. [Direct control of mitochondrial function by mTOR.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
39. [GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
40. [mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
41. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
42. [Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
43. [Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
44. [Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
45. [Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
46. [Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
47. [Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
48. [Probing cellular protein complexes using single-molecule pull-down](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
49. [mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)
50. [mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345)