Mechanistic target of rapamycin kinase
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P42346
additional property: PropertyValue
  property ID: P361
  value: Protein kinase-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: serine/threonine-protein kinase TOR
additional property: PropertyValue
  property ID: P361
  value: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
additional property: PropertyValue
  property ID: P527
  value: Domain of unknown function DUF3385, target of rapamycin protein
additional property: PropertyValue
  property ID: P527
  value: PIK-related kinase, FAT
additional property: PropertyValue
  property ID: P527
  value: Phosphatidylinositol 3/4-kinase, conserved site
additional property: PropertyValue
  property ID: P637
  value: NP_063971
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: TFIIIC-class transcription factor complex binding
additional property: PropertyValue
  property ID: P680
  value: protein kinase activity
additional property: PropertyValue
  property ID: P681
  value: Golgi membrane
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P682
  value: regulation of cell growth
additional property: PropertyValue
  property ID: P682
  value: regulation of protein phosphorylation
additional property: PropertyValue
  property ID: P682
  value: negative regulation of protein phosphorylation
additional property: PropertyValue
  property ID: P702
  value: Mtor
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000014167
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000070162
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000094256
confidence:
  popularity graph score:
    score: 0.006
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 47
      unique citations norm: 0.018
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 47
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P42346
    source count: 1
    confidence: 0.2
  P361:
    value: Q24726164
    source count: 1
    confidence: 0.2
    value label: Protein kinase-like domain superfamily
  P361:
    value: Q24723029
    source count: 1
    confidence: 0.2
    value label: serine/threonine-protein kinase TOR
  P361:
    value: Q41798033
    source count: 1
    confidence: 0.2
    value label: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
  P361:
    value: Q24739502
    source count: 1
    confidence: 0.2
    value label: Armadillo-like helical
  P361:
    value: Q24780424
    source count: 1
    confidence: 0.2
    value label: Armadillo-type fold
  P527:
    value: Q24769612
    source count: 1
    confidence: 0.2
    value label: Domain of unknown function DUF3385, target of rapamycin protein
  P527:
    value: Q24773556
    source count: 1
    confidence: 0.2
    value label: PIK-related kinase, FAT
  P527:
    value: Q24771855
    source count: 1
    confidence: 0.2
    value label: Phosphatidylinositol 3/4-kinase, conserved site
  P527:
    value: Q24771147
    source count: 1
    confidence: 0.2
    value label: Phosphatidylinositol 3-/4-kinase, catalytic domain
  P527:
    value: Q24721852
    source count: 1
    confidence: 0.2
    value label: FKBP12-rapamycin binding domain
  P637:
    value: NP_063971
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14876066
    source count: 1
    confidence: 0.2
    value label: TFIIIC-class transcription factor complex binding
  P680:
    value: Q14820641
    source count: 1
    confidence: 0.2
    value label: protein kinase activity
  P680:
    value: Q14326094
    source count: 8
    confidence: 1.0
    value label: protein serine/threonine kinase activity
  P680:
    value: Q167149
    source count: 2
    confidence: 0.4
    value label: protein binding
  P681:
    value: Q14598778
    source count: 1
    confidence: 0.2
    value label: Golgi membrane
  P681:
    value: Q40260
    source count: 4
    confidence: 0.8
    value label: nucleus
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P681:
    value: Q39572
    source count: 1
    confidence: 0.2
    value label: mitochondrion
  P681:
    value: Q14330611
    source count: 1
    confidence: 0.2
    value label: mitochondrial outer membrane

value: Q14859586
source count: 1
confidence: 0.2
value label: regulation of cell growth

value: Q14851946
source count: 1
confidence: 0.2
value label: regulation of protein phosphorylation

value: Q14860865
source count: 1
confidence: 0.2
value label: negative regulation of protein phosphorylation

value: Q14819846
source count: 1
confidence: 0.2
value label: positive regulation of protein phosphorylation

value: Q14865064
source count: 1
confidence: 0.2
value label: positive regulation of endothelial cell proliferation

value: Q24407787
source count: 1
confidence: 0.2
value label: Mtor

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000014167
source count: 1
confidence: 0.2

value: ENSRNOP00000070162
source count: 1
confidence: 0.2

value: ENSRNOP00000094256
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation
stated in qid: Q28580287
retrieved: 2019-05-09

source: Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling
stated in qid: Q28565860
retrieved: 2019-05-09

source: Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2
stated in qid: Q28575983
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites
stated in qid: Q28569134
retrieved: 2019-05-09

source: DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
stated in qid: Q24311448
retrieved: 2019-05-09

source: PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways
stated in qid: Q28565929
retrieved: 2019-05-09

source: Characterization of ubiquilin 1, an mTOR-interacting protein
stated in qid: Q24292327
retrieved: 2019-05-09

source: Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
stated in qid: Q28305483
retrieved: 2019-05-09

source: A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
stated in qid: Q33898132
retrieved: 2019-05-09

source: Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium
stated in qid: Q29347071
retrieved: 2019-05-09

source: Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation
stated in qid: Q28568907
retrieved: 2019-05-09

source: Hippocampal long term memory: effect of the cholinergic system on local protein synthesis
stated in qid: Q28564179
retrieved: 2019-05-09

source: Activation of mammalian target of rapamycin signaling in spatial learning
stated in qid: Q28564584
retrieved: 2019-05-09

source: Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway
stated in qid: Q28566602
retrieved: 2019-05-09

source: mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1–JNK pathway
stated in qid: Q28583302
retrieved: 2019-05-09

source: Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways
stated in qid: Q28584332
retrieved: 2019-05-09

source: Aβ40 modulates GABAA receptor α6 subunit expression and rat cerebellar granule neuron maturation through the ERK/mTOR pathway
stated in qid: Q28572371
retrieved: 2019-05-09

source: Repetitive stretch suppresses denervation-induced atrophy of soleus muscle in rats
stated in qid: Q28572887
retrieved: 2019-05-09

source: Effects of leucine supplementation and resistance training on myopathy of diabetic rats
stated in qid: Q41999349
retrieved: 2019-05-09

source: The mechanisms of EGFR in the regulation of axon regeneration
stated in qid: Q28577674
retrieved: 2019-05-09

source: Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
stated in qid: Q28578379
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2019-01-14

source: Hypothalamic mTOR signaling regulates food intake
stated in qid: Q28239714
retrieved: 2019-05-09

source: 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia
stated in qid: Q24299992
retrieved: 2019-05-09

source: Effect of granulocyte-macrophage colony-stimulating factor on the mammalian target of sirolimus signaling pathway in the wound of rat
stated in qid: Q28577548
retrieved: 2019-05-09

source: Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization
stated in qid: Q28576991
retrieved: 2019-05-09

source: Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia
stated in qid: Q28576512
retrieved: 2019-05-09

source: Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation
stated in qid: Q28571967
retrieved: 2019-05-09

wikidata id: Q28562648
domain: protein
level: standard
html url: https://4ort.xyz/entity/mechanistic-target-of-rapamycin-kinase-q28562648
markdown url: https://4ort.xyz/entity/mechanistic-target-of-rapamycin-kinase-q28562648.md
facts url summary: https://4ort.xyz/entity/mechanistic-target-of-rapamycin-kinase-q28562648/facts.json
facts url standard: https://4ort.xyz/entity/mechanistic-target-of-rapamycin-kinase-q28562648/facts.json
facts url full: https://4ort.xyz/entity/mechanistic-target-of-rapamycin-kinase-q28562648/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-05T05:13:03.153544Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:48:25.631733+00:00Z