# Mechanistic target of rapamycin kinase

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28562648](https://www.wikidata.org/wiki/Q28562648)  
**Source**: https://4ort.xyz/entity/mechanistic-target-of-rapamycin-kinase-q28562648


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P42346)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
5. [Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
6. [Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
7. [Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
9. [Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
10. [DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
11. [PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
12. [Characterization of ubiquilin 1, an mTOR-interacting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
13. [Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
14. [A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
15. [Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
16. [Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
17. [Hippocampal long term memory: effect of the cholinergic system on local protein synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
18. [Activation of mammalian target of rapamycin signaling in spatial learning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
19. [Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
20. [mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1–JNK pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
21. [Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
22. [Aβ40 modulates GABAA receptor α6 subunit expression and rat cerebellar granule neuron maturation through the ERK/mTOR pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
23. [Repetitive stretch suppresses denervation-induced atrophy of soleus muscle in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
24. [Effects of leucine supplementation and resistance training on myopathy of diabetic rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
25. [The mechanisms of EGFR in the regulation of axon regeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
26. [Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42346&geneProductId=UniProtKB:P42346)
28. [Hypothalamic mTOR signaling regulates food intake](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
29. [5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
30. [Effect of granulocyte-macrophage colony-stimulating factor on the mammalian target of sirolimus signaling pathway in the wound of rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
31. [Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
32. [Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
33. [Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
34. [Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
35. [Mammalian target of rapamycin is activated in association with myometrial proliferation during pregnancy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
36. [The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
37. [Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
38. [CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
39. [mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
40. [Adenosine 5'-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
41. [Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats: focus on ghrelin and nesfatin‐1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
42. [Activation of the PI3K/mTOR Pathway Is Involved in Cystic Proliferation of Cholangiocytes of the PCK Rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
43. [Activation of mammalian target of rapamycin contributes to pain nociception induced in rats by BmK I, a sodium channel-specific modulator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
44. [Cross Talk Between Estradiol and mTOR Kinase in the Regulation of Ovarian Granulosa Proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
45. [Testosterone signals through mTOR and androgen receptor to induce muscle hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
46. [MTOR downregulates iodide uptake in thyrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42346)
47. ensembl Release 106