# Mechanistic target of rapamycin kinase

> mammalian protein found in Mus musculus

**Wikidata**: [Q14876092](https://www.wikidata.org/wiki/Q14876092)  
**Source**: https://4ort.xyz/entity/mechanistic-target-of-rapamycin-kinase-q14876092


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9JLN9)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
5. [Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
6. [Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9)
8. [AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9)
9. [Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9)
10. [FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9)
11. [mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
12. [PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
13. [AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
14. [5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
15. [PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
16. [Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
17. [Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
18. [mTORC1 promotes survival through translational control of Mcl-1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
19. [Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
20. [The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
21. [Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
22. [Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
23. [mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
24. [mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
25. [Huntingtin functions as a scaffold for selective macroautophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
26. [Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
27. [FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
28. [Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
30. [Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9)
31. [GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9)
32. [Lkb1 deficiency causes prostate neoplasia in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9)
33. [Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
34. [Lkb1 deficiency causes prostate neoplasia in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
35. [GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
36. [Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
37. [Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
38. [Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
39. [Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
40. [MicroRNA-23a promotes myelination in the central nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
41. [Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
42. [Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
43. [Regulation of myoblast differentiation by the nuclear envelope protein NET39](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
44. [Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
45. [Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)
46. [Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9)
47. [Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9)
48. [Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9)
49. [miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9)
50. [Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9)