# MDS1 and EVI1 complex locus

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21114217](https://www.wikidata.org/wiki/Q21114217)  
**Source**: https://4ort.xyz/entity/mds1-and-evi1-complex-locus


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q03112)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
5. [Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03112&geneProductId=UniProtKB:Q03112)
6. [The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
7. [Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
8. [EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
9. [Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
10. [UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
11. [Phospho-tyrosine dependent protein-protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
12. [Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
13. [Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03112&geneProductId=UniProtKB:Q03112)
15. [Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
16. [Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
17. [Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03112)
18. Ensembl Release 99
19. UMLS 2023