# MDM4 regulator of p53

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109171](https://www.wikidata.org/wiki/Q21109171)  
**Source**: https://4ort.xyz/entity/mdm4-regulator-of-p53-q21109171


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O15151)
3. Q20641742
4. [MdmX is a substrate for the deubiquitinating enzyme USP2a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
5. [Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
6. [MDM2 and MDMX bind and stabilize the p53-related protein p73](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
7. [MDM4 binds ligands via a mechanism in which disordered regions become structured](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
8. [Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
9. [Systematic Analysis of Dimeric E3-RING Interactions Reveals Increased Combinatorial Complexity in Human Ubiquitination Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
10. [Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
11. [Inactivation of the p53 pathway in retinoblastoma.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
12. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
13. [14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
14. [Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
15. [An essential function of the extreme C-terminus of MDM2 can be provided by MDMX](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
16. [Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
17. [Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
18. [BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
19. [DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
20. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
21. [Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
22. [MDMX regulation of p53 response to ribosomal stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
23. [JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
24. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
25. [MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
26. [Effects of MdmX on Mdm2-mediated downregulation of pRB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
27. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
28. [Turning the RING domain protein MdmX into an active ubiquitin-protein ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
29. [The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
30. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
32. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15151&geneProductId=UniProtKB:O15151)
33. [Isolation and identification of the human homolog of a new p53-binding protein, Mdmx](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
34. [Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
35. [MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
36. [Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15151)
37. Ensembl Release 99