# MDM2 proto-oncogene

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2639180](https://www.wikidata.org/wiki/Q2639180)  
**Source**: https://4ort.xyz/entity/mdm2-proto-oncogene


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q00987)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
6. [Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
7. [Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
8. [Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
9. [Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
10. [PML regulates p53 stability by sequestering Mdm2 to the nucleolus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
11. [A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
12. [Critical role for Daxx in regulating Mdm2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
13. [The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
14. [{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
15. [Repression of p53-mediated transcription by MDM2: a dual mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
16. [The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
17. [Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
18. [BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
19. [Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
20. [Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
21. [TAF1 Differentially Enhances Androgen Receptor Transcriptional Activity via Its N-Terminal Kinase and Ubiquitin-Activating and -Conjugating Domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
22. [Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
23. [Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
24. [Monoubiquitylation promotes mitochondrial p53 translocation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
25. [Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
26. [Vimentin is a novel AKT1 target mediating motility and invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
27. [Regulation of XIAP translation and induction by MDM2 following irradiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
28. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
29. [RYBP stabilizes p53 by modulating MDM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
30. [GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
31. [ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
32. [EBV-encoded EBNA-5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
33. [DNA-damage-responsive acetylation of pRb regulates binding to E2F-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
34. [Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
35. [Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
36. [Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
37. [Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
38. [An essential function of the extreme C-terminus of MDM2 can be provided by MDMX](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
39. [Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
40. [A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
41. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
42. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
43. [14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
44. [MDMX regulation of p53 response to ribosomal stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
45. [JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
46. [Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
47. [A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
48. [Regulation of nucleolar signalling to p53 through NEDDylation of L11](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
49. [Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)
50. [Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987)