# MCM DNA helicase complex subunit MCM4 YPR019W

> fungal protein found in Saccharomyces cerevisiae S288c

**Wikidata**: [Q27549928](https://www.wikidata.org/wiki/Q27549928)  
**Source**: https://4ort.xyz/entity/mcm-dna-helicase-complex-subunit-mcm4-ypr019w


## References

1. UniProt
2. Q20641742
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P30665)
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
5. [Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
6. [Differences in the Single-stranded DNA Binding Activities of MCM2-7 and MCM467](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
7. [The Mcm467 Complex of Saccharomyces cerevisiae Is Preferentially Activated by Autonomously Replicating DNA Sequences](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
8. [The Mcm2-7 Complex Has In Vitro Helicase Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
9. [Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
10. [The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
11. [Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
12. [A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
13. [A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
14. [Structure of the eukaryotic MCM complex at 3.8 Å](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
15. [High-quality binary protein interaction map of the yeast interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
16. [A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
17. [Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
18. [Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
19. [SCF(Dia2) regulates DNA replication forks during S-phase in budding yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
20. [A new MCM modification cycle regulates DNA replication initiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
21. [Reconstitution of the Mcm2-7p Heterohexamer, Subunit Arrangement, and ATP Site Architecture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
23. [G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
24. [Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
25. [Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
26. [Formation of a Preinitiation Complex by S-phase Cyclin CDK-Dependent Loading of Cdc45p onto Chromatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
27. [GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
28. [Components and Dynamics of DNA Replication Complexes in S. cerevisiae: Redistribution of MCM Proteins and Cdc45p during S Phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
29. [The architecture of a eukaryotic replisome.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
30. [Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
31. [A group of interacting yeast DNA replication genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
32. [Uninterrupted MCM2-7 Function Required for DNA Replication Fork Progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665)
33. ensembl Release 106