MARVEL domain containing 2
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: MARVEL domain-containing protein 2
additional property: PropertyValue
  property ID: P361
  value: Putative uncharacterized transport proteins
additional property: PropertyValue
  property ID: P361
  value: Occludin homology domain, protein family
additional property: PropertyValue
  property ID: P486
  value: D062794
additional property: PropertyValue
  property ID: P527
  value: Occludin homology domain
additional property: PropertyValue
  property ID: P527
  value: Marvel domain
additional property: PropertyValue
  property ID: P637
  value: NP_001033692
additional property: PropertyValue
  property ID: P637
  value: NP_001231663
additional property: PropertyValue
  property ID: P637
  value: XP_005248502
additional property: PropertyValue
  property ID: P672
  value: D12.776.543.488.249
additional property: PropertyValue
  property ID: P672
  value: D12.776.543.940.675
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: establishment of endothelial barrier
additional property: PropertyValue
  property ID: P682
  value: cell-cell junction organization
additional property: PropertyValue
  property ID: P682
  value: hearing
additional property: PropertyValue
  property ID: P702
  value: MARVELD2
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000323264
additional property: PropertyValue
  property ID: P705
  value: ENSP00000396244
additional property: PropertyValue
  property ID: P705
  value: ENSP00000480044
additional property: PropertyValue
  property ID: P2892
  value: C3503765
additional property: PropertyValue
  property ID: P7260
  value: 9.B.41.2.1
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 13
      unique citations norm: 0.005
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 13
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q8N4S9
    source count: 1
    confidence: 0.2
  P361:
    value: Q24769494
    source count: 1
    confidence: 0.2
    value label: MARVEL domain-containing protein 2
  P361:
    value: Q69534081
    source count: 1
    confidence: 0.2
    value label: Putative uncharacterized transport proteins
  P361:
    value: Q83138969
    source count: 1
    confidence: 0.2
    value label: Occludin homology domain, protein family
  P361:
    value: Q83138676
    source count: 1
    confidence: 0.2
    value label: Marvel domain, protein family
  P486:
    value: D062794
    source count: 0
    confidence: 0.0
  P527:
    value: Q24766929
    source count: 1
    confidence: 0.2
    value label: Occludin homology domain
  P527:
    value: Q24769176
    source count: 1
    confidence: 0.2
    value label: Marvel domain
  P637:
    value: NP_001033692
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001231663
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005248502
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005248503
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005248504
    source count: 1
    confidence: 0.2
  P672:
    value: D12.776.543.488.249
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.543.940.675
    source count: 0
    confidence: 0.0
  P680:
    value: Q167149
    source count: 3
    confidence: 0.6
    value label: protein binding
  P681:
    value: Q79899
    source count: 1
    confidence: 0.2
    value label: cytoplasm
  P681:
    value: Q14327652
    source count: 1
    confidence: 0.2
    value label: integral component of membrane
  P681:
    value: Q29548
    source count: 1
    confidence: 0.2
    value label: plasma membrane
  P681:
    value: Q14864700
    source count: 1
    confidence: 0.2
    value label: basolateral plasma membrane
  P681:
    value: Q14819446
    source count: 1
    confidence: 0.2
    value label: apical plasma membrane
  P682:
    value: Q21100620
    source count: 1
    confidence: 0.2
    value label: establishment of endothelial barrier

value: Q14889767
source count: 3
confidence: 0.6
value label: cell-cell junction organization

value: Q160289
source count: 4
confidence: 0.8
value label: hearing

value: Q14883370
source count: 2
confidence: 0.4
value label: bicellular tight junction assembly

value: Q18052235
source count: 1
confidence: 0.2
value label: MARVELD2

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000323264
source count: 1
confidence: 0.2

value: ENSP00000396244
source count: 1
confidence: 0.2

value: ENSP00000480044
source count: 1
confidence: 0.2

value: ENSP00000480068
source count: 1
confidence: 0.2

value: ENSP00000398922
source count: 1
confidence: 0.2

value: C3503765
source count: 1
confidence: 0.2

value: 9.B.41.2.1
source count: 2
confidence: 0.4

source: Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.
stated in qid: Q50917009
retrieved: 2019-04-08

source: Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions
stated in qid: Q24299926
retrieved: 2019-04-08

source: Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions.
stated in qid: Q36517183
retrieved: 2019-04-08

source: Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions
stated in qid: Q24301050
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-02-27

source: Tricellulin is a tight-junction protein necessary for hearing
stated in qid: Q24337885
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: UMLS 2023
stated in qid: Q118645236
retrieved: 2023-05-25

source: Transporter Classification database
stated in qid: Q142667
retrieved: 2020-03-13

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21120817
domain: protein
level: standard
html url: https://4ort.xyz/entity/marvel-domain-containing-2
markdown url: https://4ort.xyz/entity/marvel-domain-containing-2.md
facts url summary: https://4ort.xyz/entity/marvel-domain-containing-2/facts.json
facts url standard: https://4ort.xyz/entity/marvel-domain-containing-2/facts.json
facts url full: https://4ort.xyz/entity/marvel-domain-containing-2/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-23T12:03:41.575136Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:50.900290+00:00Z