MAP kinase kinase kinase
type: Thing
alternate name: mitogen-activated protein kinase kinase kinase
alternate name: ATP:protein phosphotransferase (MAPKKKK-activated)
alternate name: MEK kinase
alternate name: MEKK
alternate name: MAPK/ERK kinase kinase
alternate name: MAPKKK
alternate name: MAP kinase kinase kinases
description: class of enzymes
additional property: PropertyValue
  property ID: P31
  value: group or class of enzymes
additional property: PropertyValue
  property ID: P279
  value: transferase
additional property: PropertyValue
  property ID: P279
  value: protein-serine-threonine kinases
additional property: PropertyValue
  property ID: P486
  value: D020930
additional property: PropertyValue
  property ID: P591
  value: 2.7.11.25
additional property: PropertyValue
  property ID: P646
  value: /m/02p7m1_
additional property: PropertyValue
  property ID: P672
  value: D08.811.913.696.620.682.700.559
additional property: PropertyValue
  property ID: P672
  value: D12.776.476.563.554
additional property: PropertyValue
  property ID: P680
  value: MAP kinase kinase kinase activity
additional property: PropertyValue
  property ID: P6366
  value: 137361374
additional property: PropertyValue
  property ID: P10283
  value: C137361374
confidence:
  popularity graph score:
    score: 0.005
    score pct: 0
    tier: long_tail
    components:
      sitelinks: 5
      sitelinks norm: 0.012
      unique citations: 3
      unique citations norm: 0.001
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 5
  unique citations: 3
  monthly pageviews: 0
  yearly pageviews: 147
  pageview trend:
    m: 2026-06
    v: 80
  pageview trend:
    m: 2026-05
    v: 19
  pageview trend:
    m: 2026-05
    v: 4
  pageview trend:
    m: 2026-04
    v: 44
  popularity:
    sitelinks: 5
    max: 423
    pct: 1.2
  tier: long_tail
claims:
  P31:
    value: Q67015883
    source count: 1
    confidence: 0.2
    value label: group or class of enzymes
  P279:
    value: Q407355
    source count: 1
    confidence: 0.2
    value label: transferase
  P279:
    value: Q4857068
    source count: 1
    confidence: 0.2
    value label: protein-serine-threonine kinases
  P486:
    value: D020930
    source count: 0
    confidence: 0.0
  P591:
    value: 2.7.11.25
    source count: 1
    confidence: 0.2
  P646:
    value: /m/02p7m1_
    source count: 0
    confidence: 0.0
  P672:
    value: D08.811.913.696.620.682.700.559
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.476.563.554
    source count: 0
    confidence: 0.0
  P680:
    value: Q14865542
    source count: 1
    confidence: 0.2
    value label: MAP kinase kinase kinase activity
  P6366:
    value: 137361374
    source count: 0
    confidence: 0.0
  P10283:
    value: C137361374
    source count: 1
    confidence: 0.2
citations:
  source: OpenAlex
  stated in qid: Q107507571
  retrieved: 2022-01-26
citations:
  retrieved: 2019-09-09
citations:
  source: InterPro release 2019-Nov-12
  stated in qid: Q77546004
meta:
  wikidata id: Q6714442
  domain: group_or_class_of_enzymes
  level: standard
  html url: https://4ort.xyz/entity/map-kinase-kinase-kinase
  markdown url: https://4ort.xyz/entity/map-kinase-kinase-kinase.md
  facts url summary: https://4ort.xyz/entity/map-kinase-kinase-kinase/facts.json
  facts url standard: https://4ort.xyz/entity/map-kinase-kinase-kinase/facts.json
  facts url full: https://4ort.xyz/entity/map-kinase-kinase-kinase/facts.json
  data source: Wikidata (CC0 / public domain)
  license: https://creativecommons.org/publicdomain/zero/1.0/
  api version: v1
  served at: 2026-08-13T03:58:54.358692Z
  entity updated at: 2026-05-03T22:54:58.348740+00:00Z
  entity created at: 2026-04-10T23:51:50.561771+00:00Z