Major intrinsic protein of lens fiber
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P30301
additional property: PropertyValue
  property ID: P361
  value: aquaporin
additional property: PropertyValue
  property ID: P361
  value: Aquaporin-like
additional property: PropertyValue
  property ID: P361
  value: Aquaporin-0
additional property: PropertyValue
  property ID: P527
  value: Major intrinsic protein, conserved site
additional property: PropertyValue
  property ID: P637
  value: NP_036196
additional property: PropertyValue
  property ID: P637
  value: XP_011536656
additional property: PropertyValue
  property ID: P637
  value: XP_016874795
additional property: PropertyValue
  property ID: P680
  value: calmodulin binding
additional property: PropertyValue
  property ID: P680
  value: structural constituent of eye lens
additional property: PropertyValue
  property ID: P680
  value: water channel activity
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: response to stimulus
additional property: PropertyValue
  property ID: P682
  value: water transport
additional property: PropertyValue
  property ID: P682
  value: ion transmembrane transport
additional property: PropertyValue
  property ID: P702
  value: MIP
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000498622
confidence:
  popularity graph score:
    score: 0.005
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 36
      unique citations norm: 0.014
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 36
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P30301
    source count: 1
    confidence: 0.2
  P361:
    value: Q623090
    source count: 1
    confidence: 0.2
    value label: aquaporin
  P361:
    value: Q24725005
    source count: 1
    confidence: 0.2
    value label: Aquaporin-like
  P361:
    value: Q26991412
    source count: 1
    confidence: 0.2
    value label: Aquaporin-0
  P361:
    value: Q95352498
    source count: 1
    confidence: 0.2
    value label: Major intrinsic protein, conserved site, protein family
  P527:
    value: Q24774701
    source count: 1
    confidence: 0.2
    value label: Major intrinsic protein, conserved site
  P637:
    value: NP_036196
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011536656
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016874795
    source count: 1
    confidence: 0.2
  P680:
    value: Q14819275
    source count: 1
    confidence: 0.2
    value label: calmodulin binding
  P680:
    value: Q14864858
    source count: 1
    confidence: 0.2
    value label: structural constituent of eye lens
  P680:
    value: Q14902498
    source count: 27
    confidence: 1.0
    value label: water channel activity
  P680:
    value: Q14863374
    source count: 1
    confidence: 0.2
    value label: channel activity
  P680:
    value: Q14902498
    source count: 28
    confidence: 1.0
    value label: water channel activity
  P681:
    value: Q14327652
    source count: 1
    confidence: 0.2
    value label: integral component of membrane
  P681:
    value: Q14349455
    source count: 2
    confidence: 0.4
    value label: membrane
  P681:
    value: Q29548
    source count: 4
    confidence: 0.8
    value label: plasma membrane
  P681:
    value: Q189073
    source count: 1
    confidence: 0.2
    value label: cell junction
  P681:
    value: Q14819446
    source count: 1
    confidence: 0.2
    value label: apical plasma membrane
  P682:
    value: Q14859560
    source count: 1
    confidence: 0.2
    value label: response to stimulus
  P682:
    value: Q14820652
    source count: 3
    confidence: 0.6
    value label: water transport
  P682:
    value: Q14865154
    source count: 1
    confidence: 0.2
    value label: ion transmembrane transport
  P682:
    value: Q14911569
    source count: 1
    confidence: 0.2
    value label: lens development in camera-type eye
  P682:
    value: Q14819258
    source count: 1
    confidence: 0.2
    value label: protein homotetramerization

value: Q18029134
source count: 1
confidence: 0.2
value label: MIP

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000498622
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-09-10

source: Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion
stated in qid: Q28115831
retrieved: 2018-09-10

source: Aquaporin-1, nothing but a water channel.
stated in qid: Q27919648
retrieved: 2018-09-10

source: The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers
stated in qid: Q27876231
retrieved: 2018-09-10

source: Water permeability and characterization of aquaporin-11.
stated in qid: Q28000039
retrieved: 2018-09-10

source: Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia
stated in qid: Q28118403
retrieved: 2018-09-10

source: Purification and functional characterization of aquaporin-8.
stated in qid: Q27919674
retrieved: 2018-09-10

source: Mercury-Sensitive Residues and Pore Site in AQP3 Water Channel
stated in qid: Q28115565
retrieved: 2018-09-10

source: Functional characterization and localization of AQP3 in the human colon
stated in qid: Q27876217
retrieved: 2018-09-10

source: Novel variants in human Aquaporin-4 reduce cellular water permeability
stated in qid: Q24645968
retrieved: 2018-09-10

source: Functional impairment of lens aquaporin in two families with dominantly inherited cataracts
stated in qid: Q27876227
retrieved: 2018-09-10

source: Mechanism of selectivity in aquaporins and aquaglyceroporins.
stated in qid: Q27919717
retrieved: 2018-09-10

source: Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein
stated in qid: Q27919643
retrieved: 2018-09-10

source: Functional characterization of human aquaporin 9 as a facilitative glycerol carrier.
stated in qid: Q27967623
retrieved: 2018-09-10

source: Functional characterization of a human aquaporin 0 mutation that leads to a congenital dominant lens cataract
stated in qid: Q27924190
retrieved: 2018-09-10

source: Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues
stated in qid: Q28115321
retrieved: 2018-09-10

source: Molecular Cloning and Expression of a Novel Human Aquaporin from Adipose Tissue with Glycerol Permeability
stated in qid: Q24314415
retrieved: 2018-09-10

source: Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5
stated in qid: Q28117298
retrieved: 2018-09-10

source: Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.
stated in qid: Q27919694
retrieved: 2018-09-10

source: Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein
stated in qid: Q27919654
retrieved: 2018-09-10

source: Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin
stated in qid: Q27919626
retrieved: 2018-09-10

source: Structural determinants of water permeation through aquaporin-1
stated in qid: Q27627493
retrieved: 2018-09-10

source: Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene
stated in qid: Q22007966
retrieved: 2018-09-10

source: Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum
stated in qid: Q27919617
retrieved: 2018-09-10

source: Functional and molecular characterization of the human neutral solute channel aquaporin-9.
stated in qid: Q27876218
retrieved: 2018-09-10

source: Identification of arylsulfonamides as Aquaporin 4 inhibitors
stated in qid: Q27919706
retrieved: 2018-09-10

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-01-01

source: Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion
stated in qid: Q28115831
retrieved: 2018-01-01

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-01-01

wikidata id: Q21122978
domain: protein
level: standard
html url: https://4ort.xyz/entity/major-intrinsic-protein-of-lens-fiber
markdown url: https://4ort.xyz/entity/major-intrinsic-protein-of-lens-fiber.md
facts url summary: https://4ort.xyz/entity/major-intrinsic-protein-of-lens-fiber/facts.json
facts url standard: https://4ort.xyz/entity/major-intrinsic-protein-of-lens-fiber/facts.json
facts url full: https://4ort.xyz/entity/major-intrinsic-protein-of-lens-fiber/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-08T03:18:32.536331Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:12:18.107337+00:00Z