major histocompatibility complex, class I, G
type: Thing
alternate name: HLA G antigen
alternate name: mutant MHC class Ib antigen
alternate name: b2 microglobulin
alternate name: HLA-G
alternate name: HLA-G histocompatibility antigen, class I, G
alternate name: MHC class I antigen G
alternate name: HLA class I histocompatibility antigen, alpha chain G
alternate name: mutant MHC class I antigen
alternate name: MHC class Ib antigen
alternate name: HLA-G Antigens
description: mammalian proteins found in Homo sapiens
additional property: PropertyValue
  property ID: P18
  value: Protein HLA-G PDB 1ydp.png
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P31
  value: major histocompatibility complex
additional property: PropertyValue
  property ID: P352
  value: P17693
additional property: PropertyValue
  property ID: P361
  value: Immunoglobulin-like fold
additional property: PropertyValue
  property ID: P361
  value: Immunoglobulin-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: MHC classes I/II-like antigen recognition protein
additional property: PropertyValue
  property ID: P486
  value: D059951
additional property: PropertyValue
  property ID: P527
  value: immunoglobulin C1-set
additional property: PropertyValue
  property ID: P527
  value: Immunoglobulin/major histocompatibility complex, conserved site
additional property: PropertyValue
  property ID: P527
  value: immunoglobulin-like domain
additional property: PropertyValue
  property ID: P637
  value: NP_002118
additional property: PropertyValue
  property ID: P637
  value: XP_016866306
additional property: PropertyValue
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  value: XP_016866307
additional property: PropertyValue
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  value: 3KYO
additional property: PropertyValue
  property ID: P638
  value: 1YDP
additional property: PropertyValue
  property ID: P638
  value: 2D31
additional property: PropertyValue
  property ID: P646
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additional property: PropertyValue
  property ID: P672
  value: D12.776.395.550.489.700
additional property: PropertyValue
  property ID: P672
  value: D12.776.543.550.439.700
additional property: PropertyValue
  property ID: P672
  value: D23.050.301.500.100.700
additional property: PropertyValue
  property ID: P680
  value: protein homodimerization activity
additional property: PropertyValue
  property ID: P680
  value: signaling receptor binding
additional property: PropertyValue
  property ID: P680
  value: peptide antigen binding
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: phagocytic vesicle membrane
additional property: PropertyValue
  property ID: P681
  value: early endosome membrane
additional property: PropertyValue
  property ID: P682
  value: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
additional property: PropertyValue
  property ID: P682
  value: positive regulation of tolerance induction
additional property: PropertyValue
  property ID: P682
  value: positive regulation of interleukin-12 production
confidence:
  popularity graph score:
    score: 0.013
    score pct: 1
    tier: established
    components:
      sitelinks: 9
      sitelinks norm: 0.021
      unique citations: 37
      unique citations norm: 0.015
      monthly pageviews: 85
      monthly pageviews norm: 0.0
  sitelinks: 9
  unique citations: 37
  monthly pageviews: 85
  yearly pageviews: 152
  pageview trend:
    m: 2026-08
    v: 85
  pageview trend:
    m: 2026-07
    v: 8
  pageview trend:
    m: 2026-06
    v: 15
  pageview trend:
    m: 2026-05
    v: 1
  pageview trend:
    m: 2026-05
    v: 9
  pageview trend:
    m: 2026-05
    v: 5
  pageview trend:
    m: 2026-04
    v: 1
  pageview trend:
    m: 2026-04
    v: 1
  pageview trend:
    m: 2026-04
    v: 27
  popularity:
    sitelinks: 9
    max: 423
    pct: 2.1
  tier: established
claims:
  P18:
    value: Protein HLA-G PDB 1ydp.png
    source count: 0
    confidence: 0.0
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P31:
    value: Q423163
    source count: 0
    confidence: 0.0
    value label: major histocompatibility complex
  P352:
    value: P17693
    source count: 1
    confidence: 0.2
  P361:
    value: Q24787648
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin-like fold
  P361:
    value: Q41797304
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin-like domain superfamily
  P361:
    value: Q24783841
    source count: 1
    confidence: 0.2
    value label: MHC classes I/II-like antigen recognition protein
  P361:
    value: Q41798146
    source count: 1
    confidence: 0.2
    value label: MHC class I-like antigen recognition-like superfamily
  P361:
    value: Q83141078
    source count: 1
    confidence: 0.2
    value label: MHC class I-like antigen recognition-like, protein family
  P486:
    value: D059951
    source count: 0
    confidence: 0.0
  P527:
    value: Q24780101
    source count: 1
    confidence: 0.2
    value label: immunoglobulin C1-set

value: Q24727222
source count: 1
confidence: 0.2
value label: Immunoglobulin/major histocompatibility complex, conserved site

value: Q24783253
source count: 1
confidence: 0.2
value label: immunoglobulin-like domain

value: Q24784700
source count: 1
confidence: 0.2
value label: MHC class I alpha chain, alpha1 alpha2 domains

value: Q24773588
source count: 1
confidence: 0.2
value label: MHC class I-like antigen recognition-like

value: NP_002118
source count: 1
confidence: 0.2

value: XP_016866306
source count: 1
confidence: 0.2

value: XP_016866307
source count: 1
confidence: 0.2

value: XP_024302188
source count: 1
confidence: 0.2

value: NP_001350496
source count: 1
confidence: 0.2

value: 3KYO
source count: 1
confidence: 0.2

value: 1YDP
source count: 1
confidence: 0.2

value: 2D31
source count: 1
confidence: 0.2

value: 2DYP
source count: 1
confidence: 0.2

value: 3BZE
source count: 1
confidence: 0.2

value: /m/03cq18m
source count: 0
confidence: 0.0

value: D12.776.395.550.489.700
source count: 0
confidence: 0.0

value: D12.776.543.550.439.700
source count: 0
confidence: 0.0

value: D23.050.301.500.100.700
source count: 0
confidence: 0.0

value: D23.050.301.500.450.700
source count: 0
confidence: 0.0

value: D23.050.705.552.100.700
source count: 0
confidence: 0.0

value: Q14762996
source count: 3
confidence: 0.6
value label: protein homodimerization activity

value: Q14819233
source count: 2
confidence: 0.4
value label: signaling receptor binding

value: Q14599293
source count: 1
confidence: 0.2
value label: peptide antigen binding

value: Q167149
source count: 12
confidence: 1.0
value label: protein binding

value: Q14762994
source count: 2
confidence: 0.4
value label: identical protein binding

value: Q14327652
source count: 1
confidence: 0.2
value label: integral component of membrane

value: Q14875827
source count: 1
confidence: 0.2
value label: phagocytic vesicle membrane

value: Q14864702
source count: 1
confidence: 0.2
value label: early endosome membrane

value: Q14349455
source count: 2
confidence: 0.4
value label: membrane

value: Q14598778
source count: 1
confidence: 0.2
value label: Golgi membrane

value: Q14633881
source count: 1
confidence: 0.2
value label: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

value: Q22302065
source count: 1
confidence: 0.2
value label: positive regulation of tolerance induction

value: Q14864550
source count: 1
confidence: 0.2
value label: positive regulation of interleukin-12 production

value: Q14865330
source count: 1
confidence: 0.2
value label: interferon-gamma-mediated signaling pathway

value: Q14916317
source count: 1
confidence: 0.2
value label: immune system process

value: PBB GE HLA-G 211529 x at fs.png
source count: 0
confidence: 0.0

value: PBB GE HLA-G 211528 x at fs.png
source count: 0
confidence: 0.0

value: PBB GE HLA-G 210514 x at fs.png
source count: 0
confidence: 0.0

value: Q21163350
source count: 1
confidence: 0.2
value label: HLA-G

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000449903
source count: 1
confidence: 0.2

value: ENSP00000353472
source count: 1
confidence: 0.2

value: ENSP00000373116
source count: 1
confidence: 0.2

value: ENSP00000388176
source count: 1
confidence: 0.2

value: ENSP00000389522
source count: 1
confidence: 0.2

value: 2780027760
source count: 0
confidence: 0.0

value: C2780027760
source count: 1
confidence: 0.2

source: Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway
stated in qid: Q24321398
retrieved: 2019-04-08

source: Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors
stated in qid: Q24293562
retrieved: 2019-04-08

source: Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function
stated in qid: Q44521264
retrieved: 2019-04-08

source: Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors
stated in qid: Q24293562
retrieved: 2017-10-31

source: Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2
stated in qid: Q24295002
retrieved: 2017-10-31

source: GOA
stated in qid: Q28018111
retrieved: 2017-10-31

source: Calreticulin associates with non‐HLA‐A,‐B class I proteins in the human choriocarcinoma cell lines JEG‐3 and BeWo
stated in qid: Q47927314
retrieved: 2019-04-08

source: The truncated cytoplasmic tail of HLA-G serves a quality-control function in post-ER compartments
stated in qid: Q43718346
retrieved: 2019-04-08

source: A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells
stated in qid: Q24676716
retrieved: 2019-04-08

source: Activation of NK cells by an endocytosed receptor for soluble HLA-G.
stated in qid: Q24813830
retrieved: 2019-04-08

source: Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells
stated in qid: Q60273498
retrieved: 2019-04-08

source: Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G
stated in qid: Q24678795
retrieved: 2019-04-08

source: An essential function of tapasin in quality control of HLA-G molecules
stated in qid: Q42805399
retrieved: 2019-04-08

source: Tyrosine nitration in the human leucocyte antigen-G-binding domain of the Ig-like transcript 2 protein
stated in qid: Q39828090
retrieved: 2019-04-08

source: Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)
stated in qid: Q35133849
retrieved: 2019-04-08

source: A motif in LILRB2 critical for Angptl2 binding and activation.
stated in qid: Q34019602
retrieved: 2019-04-08

source: Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.
stated in qid: Q46925575
retrieved: 2019-04-08

source: Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2
stated in qid: Q24295002
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: The Structure and Stability of the Monomorphic HLA-G Are Influenced by the Nature of the Bound Peptide
stated in qid: Q27659367
retrieved: 2019-04-08

source: Nonclassical HLA-G molecules are classical peptide presenters
stated in qid: Q41220845
retrieved: 2019-04-08

source: The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association
stated in qid: Q41278544
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Defining the membrane proteome of NK cells
stated in qid: Q24323157
retrieved: 2017-10-31

source: HLA-G2, -G3, and -G4 isoforms expressed as nonmature cell surface glycoproteins inhibit NK and antigen-specific CTL cytolysis
stated in qid: Q33941618
retrieved: 2019-04-08

source: Defining the membrane proteome of NK cells
stated in qid: Q24323157
retrieved: 2019-04-08

source: Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
stated in qid: Q24310325
retrieved: 2019-04-08

source: HLA-G expression in melanoma: a way for tumor cells to escape from immunosurveillance
stated in qid: Q24323589
retrieved: 2019-04-08

source: Binding of HLA-G to ITIM-bearing Ig-like transcript 2 receptor suppresses B cell responses
stated in qid: Q39266544
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-01-01

wikidata id: Q3124896
domain: protein
level: standard
html url: https://4ort.xyz/entity/major-histocompatibility-complex-class-i-g
markdown url: https://4ort.xyz/entity/major-histocompatibility-complex-class-i-g.md
facts url summary: https://4ort.xyz/entity/major-histocompatibility-complex-class-i-g/facts.json
facts url standard: https://4ort.xyz/entity/major-histocompatibility-complex-class-i-g/facts.json
facts url full: https://4ort.xyz/entity/major-histocompatibility-complex-class-i-g/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T01:07:37.355318Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-04-10T23:57:44.543306+00:00Z