# Lysine methyltransferase 2A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21102206](https://www.wikidata.org/wiki/Q21102206)  
**Source**: https://4ort.xyz/entity/lysine-methyltransferase-2a


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q03164)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
5. [Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
6. [Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
7. [Divergent hTAFII31-binding motifs hidden in activation domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
8. [Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
9. [Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03164&geneProductId=UniProtKB:Q03164)
11. [Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
12. [Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
13. [On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
14. [The histone methyltransferase MLL1 permits the oscillation of circadian gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
15. [Structural basis for activity regulation of MLL family methyltransferases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
16. [The mutational landscape of lethal castration-resistant prostate cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
17. [Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
18. [Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
19. [WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
20. [Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
21. [A High-Density Map for Navigating the Human Polycomb Complexome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
22. [NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
23. [SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
24. [The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
25. [The same pocket in menin binds both MLL and JUND but has opposite effects on transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
26. [Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
27. [Structural and Biochemical Insights into MLL1 Core Complex Assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
28. [Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
29. [Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
30. [The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
31. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
33. [Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
34. [Human RNA Polymerase II-Association Factor 1 (hPaf1/PD2) Regulates Histone Methylation and Chromatin Remodeling in Pancreatic Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
35. [Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
36. [Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03164&geneProductId=UniProtKB:Q03164)
37. [Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03164&geneProductId=UniProtKB:Q03164)
38. [New insight into the molecular mechanisms of MLL-associated leukemia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03164&geneProductId=UniProtKB:Q03164)
39. [Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03164&geneProductId=UniProtKB:Q03164)
40. [New insight into the molecular mechanisms of MLL-associated leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164)
41. ensembl Release 93
42. UMLS 2023