# lysine demethylase 1A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21108161](https://www.wikidata.org/wiki/Q21108161)  
**Source**: https://4ort.xyz/entity/lysine-demethylase-1a-q21108161


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL4297289)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O60341)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
7. [TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
8. [p53 is regulated by the lysine demethylase LSD1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60341&geneProductId=UniProtKB:O60341)
10. [Histone demethylation mediated by the nuclear amine oxidase homolog LSD1](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60341&geneProductId=UniProtKB:O60341)
11. [Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
12. [SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
13. [A human protein-protein interaction network: a resource for annotating the proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
14. [Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
15. [Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
16. [Structural basis of LSD1-CoREST selectivity in histone H3 recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
17. [The functional interactome landscape of the human histone deacetylase family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
18. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
19. [NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
20. [A rationally‐designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
21. [Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
22. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
23. [PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
24. [The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
25. [The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
26. [A Y2H-seq approach defines the human protein methyltransferase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
27. [LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
28. [LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
29. [LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
30. [Histone demethylation mediated by the nuclear amine oxidase homolog LSD1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
31. [LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60341&geneProductId=UniProtKB:O60341)
32. [Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60341&geneProductId=UniProtKB:O60341)
33. [The histone demethylase LSD1/KDM1A promotes the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60341&geneProductId=UniProtKB:O60341)
34. [LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60341&geneProductId=UniProtKB:O60341)
35. [Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60341&geneProductId=UniProtKB:O60341)
36. [Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
37. [Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
38. [Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60341&geneProductId=UniProtKB:O60341)
39. [The histone demethylase LSD1/KDM1A promotes the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
40. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
41. [Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
42. [p53 is regulated by the lysine demethylase LSD1](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60341&geneProductId=UniProtKB:O60341)
43. [MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
44. [Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341)
45. Ensembl Release 99
46. UMLS 2023