# LYN proto-oncogene, Src family tyrosine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2463389](https://www.wikidata.org/wiki/Q2463389)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/LYN)  
**Source**: https://4ort.xyz/entity/lyn-proto-oncogene-src-family-tyrosine-kinase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P07948)
4. Q20641742
5. [Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
7. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07948)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
9. [The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07948)
10. [Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
11. [Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
12. [Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
13. [Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
14. [Leupaxin negatively regulates B cell receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
15. [Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
16. [Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
17. [Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
18. [Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
19. [Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
20. [ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
21. [Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
22. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
23. [Epidermal Growth Factor Receptor Potentiates MCM7-Mediated DNA Replication through Tyrosine Phosphorylation of Lyn Kinase in Human Cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
24. [Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
25. [Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
26. [Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
27. [CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
28. [DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
29. [Lyn is involved in CD24-induced ERK1/2 activation in colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
30. [Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
31. [Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
32. [The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
33. [Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
34. [Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
35. [Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
36. [The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
37. [Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
38. [Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
39. [Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
40. [Vav2 is required for cell spreading](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
41. [A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
42. [Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
43. [Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
44. [Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
45. [Protein kinase C theta is expressed in mast cells and is functionally involved in Fcepsilon receptor I signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
46. [Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
47. [Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
48. [BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
49. [The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)
50. [Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948)