# LYN proto-oncogene, Src family tyrosine kinase

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28556795](https://www.wikidata.org/wiki/Q28556795)  
**Source**: https://4ort.xyz/entity/lyn-proto-oncogene-src-family-tyrosine-kinase-q28556795


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q07014)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
5. [Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
7. [Regulation of rat basophilic leukemia-2H3 mast cell secretion by a constitutive Lyn kinase interaction with the high affinity IgE receptor (Fc epsilon RI)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
8. [SH2 Domain-Containing Inositol Polyphosphate 5′-Phosphatase Is the Main Mediator of the Inhibitory Action of the Mast Cell Function-Associated Antigen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
9. [Overcoming the signaling defect of Lyn-sequestering, signal-curtailing FcepsilonRI dimers: aggregated dimers can dissociate from Lyn and form signaling complexes with Syk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
10. [Thy-1 molecule associates with protein tyrosine kinase(s) in rat mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
11. [Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
12. [Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
13. [The Src family kinase, Lyn, is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors which stimulate its association with numerous other signaling molecules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
14. [Involvement of gangliosides in glycosylphosphatidylinositol-anchored neuronal cell adhesion molecule TAG-1 signaling in lipid rafts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
15. [The adapter molecule Gab2 regulates Fc epsilon RI-mediated signal transduction in mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
16. [Regulation of lipid raft proteins by glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C in rat adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
17. [Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
18. [Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
19. [Src family tyrosine kinase Lyn binds several proteins including paxillin in rat basophilic leukemia cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
20. [Rapid dephosphorylation of the GTPase dynamin after FcepsilonRI aggregation in a rat mast cell line](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
21. [Interactions between Src family protein tyrosine kinases and PSD-95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
22. [Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
23. [Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
24. [Protein tyrosine kinase p53/p56(lyn) forms complexes with gamma-tubulin in rat basophilic leukemia cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
25. [Src family tyrosine kinase p53/56lyn, a serine kinase and Fc epsilon RI associate with alpha-galactosyl derivatives of ganglioside GD1b in rat basophilic leukemia RBL-2H3 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
26. [The inositol 5'-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
27. [Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
28. [Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
29. [Real-time cross-correlation image analysis of early events in IgE receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
30. [Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
31. [L-DOPA treatment of parkinsonian rats changes the expression of Src, Lyn and PKC kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
32. [L-NAME reverses quinolinic acid-induced toxicity in rat corticostriatal slices: Involvement of src family kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
33. [AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3-kinase-dependent activation in extracellular signal-regulated kinase to upregulate BDNF gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
34. [Gene expression profiling of the rat endometriosis model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
35. [Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
36. [Lyn- and ERK-mediated vs. Ca2+ -mediated neutrophil O responses with thermal injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
37. [Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07014)
38. ensembl Release 106