# LYN proto-oncogene, Src family tyrosine kinase

> mammalian protein found in Mus musculus

**Wikidata**: [Q15331919](https://www.wikidata.org/wiki/Q15331919)  
**Source**: https://4ort.xyz/entity/lyn-proto-oncogene-src-family-tyrosine-kinase-q15331919


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P25911)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
5. [Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
6. [Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
7. [HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
9. [CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
10. [Leupaxin negatively regulates B cell receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
11. [Gab3, a New DOS/Gab Family Member, Facilitates Macrophage Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
12. [FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
13. [LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
14. [The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
15. [Source](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
16. [Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
18. [Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
19. [Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
20. [Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
21. [Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
22. [Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
23. [Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
24. [Involvement of the Src kinase Lyn in phospholipase C-gamma 2 phosphorylation and phosphatidylinositol 3-kinase activation in Epo signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
25. [Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
26. [Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
27. [Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
28. [Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
29. [Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
30. [The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
31. [Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
32. [An Important Role of the Src Family Kinase Lyn in Stimulating Platelet Granule Secretion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
33. [The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
34. [Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
35. [Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
36. [Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
37. [Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
38. [Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
39. [The Src kinase Lyn is a negative regulator of mast cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
40. [The Src kinase Lyn is a negative regulator of mast cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911)
41. [Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
42. [Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
43. [Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
44. [Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
45. [An Important Role of the Src Family Kinase Lyn in Stimulating Platelet Granule Secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
46. [Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
47. [Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911)
48. ensembl Release 106