# Lymphoid enhancer binding factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6708270](https://www.wikidata.org/wiki/Q6708270)  
**Source**: https://4ort.xyz/entity/lymphoid-enhancer-binding-factor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9UJU2)
3. Q20641742
4. [Swiss-Prot](http://www.uniprot.org/uniprot/P27782.txt?version=158)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
6. [Chromatin-specific regulation of LEF-1–β-catenin transcription activation and inhibition in vitro](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
7. [Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
8. [ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
9. [Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
10. [Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
12. [Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
13. [Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
14. [Human CD1D Gene Expression Is Regulated by LEF-1 through Distal Promoter Regulatory Elements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
15. [Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
16. [Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
17. [I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
18. [Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
19. [Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
20. [Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
21. [Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
22. [Vitamin D receptor is essential for normal keratinocyte stem cell function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
23. [Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
24. [The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
25. [Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
26. [A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in Xenopus](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
27. [Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
28. [Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
29. [Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
31. [Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
32. [Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
33. [Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
34. [Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
35. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
36. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
37. [Chromatin-specific regulation of LEF-1–β-catenin transcription activation and inhibition in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
38. [Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
39. [Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
40. [ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
41. [Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
42. [A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in Xenopus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
43. [Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
44. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
45. [Role of hepatitis B surface antigen in the development of hepatocellular carcinoma: regulation of lymphoid enhancer-binding factor 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
46. [LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
47. [LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2)
48. [Role of hepatitis B surface antigen in the development of hepatocellular carcinoma: regulation of lymphoid enhancer-binding factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
49. [LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)
50. [LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2)