# Lymphoid enhancer binding factor 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21498209](https://www.wikidata.org/wiki/Q21498209)  
**Source**: https://4ort.xyz/entity/lymphoid-enhancer-binding-factor-1-q21498209


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P27782)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
5. [LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
6. [Alx4 Binding to LEF-1 Regulates N-CAM Promoter Activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
7. [The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
8. [Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
10. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
11. [Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
12. [LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
13. [Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
14. [Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
15. [Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
16. [Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
17. [Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
18. [Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
19. [Alx4 Binding to LEF-1 Regulates N-CAM Promoter Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
20. [Pax3 functions at a nodal point in melanocyte stem cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
21. [PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
22. [Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
23. [Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
24. [Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
25. [Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
26. [LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
27. [The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
28. [The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
29. [Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
30. [Pax3 functions at a nodal point in melanocyte stem cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
31. [Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
32. [Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
33. [Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
34. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
35. [The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
36. [Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
37. [LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
38. [Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
39. [Shh expression is required for embryonic hair follicle but not mammary gland development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
40. [Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
41. [LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
42. [Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
43. [Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
44. [Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
45. [Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
46. [Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27782&geneProductId=UniProtKB:P27782)
47. [Shh expression is required for embryonic hair follicle but not mammary gland development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
48. [Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
49. [LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)
50. [Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27782)