# Lymphocyte protein tyrosine kinase

> mammalian protein found in Mus musculus

**Wikidata**: [Q14885208](https://www.wikidata.org/wiki/Q14885208)  
**Source**: https://4ort.xyz/entity/lymphocyte-protein-tyrosine-kinase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P06240)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
5. [Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240)
8. [LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240)
9. [Characterization of Lnk. An adaptor protein expressed in lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240)
10. [Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240)
11. [CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240)
12. [Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240)
13. [HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
14. [CAML is a p56Lck-interacting protein that is required for thymocyte development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
15. [SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
16. [Regulation of T cell development by the deubiquitinating enzyme CYLD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
17. [Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
18. [Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
19. [The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
20. [Interaction of p56lck with CD4 in the yeast two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
21. [Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
22. [Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
23. [Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
24. [CD45 and RPTPα display different protein tyrosine phosphatase activities in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
25. [Lck availability during thymic selection determines the recognition specificity of the T cell repertoire](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
26. [Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
27. [Interactions between the amino‐terminal domain of p56lck and cytoplasmic domains of CD4 and CD8α in yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
28. [The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
29. [The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
30. [LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
31. [Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
32. [Characterization of Lnk. An adaptor protein expressed in lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
33. [CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
34. [The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
35. [Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
36. [PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
37. [Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
38. [Regulation of GATA-3 expression during CD4 lineage differentiation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
39. [Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
40. [Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240)
41. ensembl Release 106
42. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
43. UMLS 2023