# Low density lipoprotein receptor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q425649](https://www.wikidata.org/wiki/Q425649)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/LDL_receptor)  
**Source**: https://4ort.xyz/entity/low-density-lipoprotein-receptor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P01130)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
6. [The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
7. [Reelin is a ligand for lipoprotein receptors](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130)
8. [The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
9. [ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
10. [LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
11. [MMP‐2 inhibits PCSK9‐induced degradation of the LDL receptor in Hepa1‐c1c7 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
12. [LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
13. [Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
14. [Molecular basis for LDL receptor recognition by PCSK9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
15. [Mode of Interaction between β2GPI and Lipoprotein Receptors Suggests Mutually Exclusive Binding of β2GPI to the Receptors and Anionic Phospholipids](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
16. [Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
17. [Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
18. [Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
19. [Reelin is a ligand for lipoprotein receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
20. [Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
21. [The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
22. [Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
23. [Analysis of a recycling-impaired mutant of low density lipoprotein receptor in familial hypercholesterolemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
24. [Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
25. [The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
26. [The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
27. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130)
28. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130)
29. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
30. [Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
31. [The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
32. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01130&geneProductId=UniProtKB:P01130)
33. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
34. [Integration of endocytosis and signal transduction by lipoprotein receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
35. [Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
36. [Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130)
37. [Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
38. [The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130)
39. [A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
40. [Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130)
41. Ensembl Release 99
42. Identifiers.org
43. UMLS 2023
44. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)