# Low density lipoprotein receptor-related protein 6

> mammalian protein found in Mus musculus

**Wikidata**: [Q21495922](https://www.wikidata.org/wiki/Q21495922)  
**Source**: https://4ort.xyz/entity/low-density-lipoprotein-receptor-related-protein-6


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O88572)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
5. [Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
6. [The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
7. [Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
8. [Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
9. [GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
10. [alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
11. [N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
12. [Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
13. [The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
14. [Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
15. [The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
16. [Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88572&geneProductId=UniProtKB:O88572)
19. [Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
20. [Genetic interaction between Lrp6 and Wnt5a during mouse development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
21. [Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
22. [Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
23. [Delayed dopaminergic neuron differentiation in Lrp6 mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
24. [Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
25. [Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
26. [Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
27. [Cardiac neural crest and outflow tract defects in Lrp6 mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
28. [Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
29. [Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
30. [Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
31. [The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
32. [The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
33. [Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
34. [Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
35. [Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
36. [Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
37. [Wnt5a regulates distinct signalling pathways by binding to Frizzled2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
38. [An LDL-receptor-related protein mediates Wnt signalling in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
39. [R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
40. [Genetic interaction between Wnt7a and Lrp6 during patterning of dorsal and posterior structures of the mouse limb](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
41. [Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
42. [Tooth development in the 'crooked' mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
43. [New semidominant mutations that affect mouse development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
44. [Crooked tail (Cd) models human folate-responsive neural tube defects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
45. [Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
46. [Genetic evidence that SOST inhibits WNT signaling in the limb](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
47. [Genes and genotypes affecting the teeth of the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572)
48. ensembl Release 106