# Low density lipoprotein receptor-related protein 5

> mammalian protein found in Mus musculus

**Wikidata**: [Q21495924](https://www.wikidata.org/wiki/Q21495924)  
**Source**: https://4ort.xyz/entity/low-density-lipoprotein-receptor-related-protein-5


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q91VN0)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
5. [Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
6. [N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
7. [SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
9. [Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
10. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
12. [Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
13. [Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
14. [Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
15. [Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
16. [Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
17. [The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
18. [The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
19. [The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
20. [The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
21. [The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
22. [Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
23. [Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
24. [WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
25. [The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
26. [Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
27. [LRP4 serves as a coreceptor of agrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
28. [Bone biomechanical properties in LRP5 mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
29. [Gender specific LRP5 influences on trabecular bone structure and strength](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
30. [PTH stimulates bone formation in mice deficient in Lrp5](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
31. [The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
32. [Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
33. [Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
34. [Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
35. [Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0)
36. [Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
37. [A model for familial exudative vitreoretinopathy caused by LPR5 mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
38. [Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
39. [High bone mass in mice expressing a mutant LRP5 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
40. [The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
41. [MiR-9-5p, miR-675-5p and miR-138-5p Damages the Strontium and LRP5-Mediated Skeletal Cell Proliferation, Differentiation, and Adhesion.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
42. [Bone biomechanical properties in LRP5 mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
43. [Gender specific LRP5 influences on trabecular bone structure and strength](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
44. [PTH stimulates bone formation in mice deficient in Lrp5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
45. [Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
46. [Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
47. [Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0)
48. ensembl Release 106