# Low density lipoprotein receptor-related protein 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21981311](https://www.wikidata.org/wiki/Q21981311)  
**Source**: https://4ort.xyz/entity/low-density-lipoprotein-receptor-related-protein-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/A2ARV4)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
5. [LRP2/megalin is required for patterning of the ventral telencephalon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
6. [Megalin interacts with APP and the intracellular adapter protein FE65 in neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
7. [Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
8. [Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
9. [LDL receptor-related protein as a component of the midkine receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
10. [Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
11. [Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
12. [Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=A2ARV4&geneProductId=UniProtKB:A2ARV4)
14. [Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
15. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
16. [Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
17. [Arf4 is required for Mammalian development but dispensable for ciliary assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
18. [LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
19. [Role of endocytosis in cellular uptake of sex steroids.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
20. [The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
21. [Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
22. [Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
23. [Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
24. [Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
25. [Global genetic analysis in mice unveils central role for cilia in congenital heart disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
26. [An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
27. [LRP2 mediates folate uptake in the developing neural tube](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
28. [Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
29. [Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
30. [Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
31. [Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
32. [Megalin-mediated endocytosis of cystatin C in proximal tubule cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
33. [Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4)
34. ensembl Release 106
35. Transporter Classification database