# Lipinski's rule of five

> rule of thumb that a compound is likely orally active if it violates at most one of: ≤5 hydrogen bond donors; ≤10 hydrogen bond acceptors; molecular mass of ≤500 Da; octanol-water partition coefficient of ≤5

**Wikidata**: [Q916723](https://www.wikidata.org/wiki/Q916723)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Lipinski's_rule_of_five)  
**Source**: https://4ort.xyz/entity/lipinski-s-rule-of-five


## References

1. Freebase Data Dumps. 2013
2. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)