# Ligase IV, DNA, ATP-dependent

> mammalian protein found in Mus musculus

**Wikidata**: [Q21495235](https://www.wikidata.org/wiki/Q21495235)  
**Source**: https://4ort.xyz/entity/ligase-iv-dna-atp-dependent


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8BTF7)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
5. [Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
6. [The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7)
8. [Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7)
9. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
10. [A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
11. [Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
12. [DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
13. [The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
14. [DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
15. [Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
16. [Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
17. [DNA repair is limiting for haematopoietic stem cells during ageing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
18. [Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
19. [DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
20. [Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
21. [Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
22. [The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
23. [IgH class switching and translocations use a robust non-classical end-joining pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
24. [Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7)
25. [The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7)
26. [Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7)
27. [DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7)
28. [Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
29. [DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7)
30. ensembl Release 106