LIF interleukin 6 family cytokine
type: Thing
alternate name: LIF
alternate name: hepatocyte-stimulating factor III
alternate name: D factor
alternate name: differentiation-stimulating factor
alternate name: differentiation inhibitory activity
alternate name: MLPLI
alternate name: cholinergic differentiation factor
alternate name: leukemia inhibitory factor
alternate name: differentiation-inducing factor
alternate name: melanoma-derived LPL inhibitor
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P15018
additional property: PropertyValue
  property ID: P361
  value: four-helical cytokine-like, core
additional property: PropertyValue
  property ID: P361
  value: Leukemia inhibitory factor
additional property: PropertyValue
  property ID: P361
  value: Leukemia inhibitory factor /oncostatin, conserved site, protein family
additional property: PropertyValue
  property ID: P373
  value: Leukemia inhibitory factor (LIF)
additional property: PropertyValue
  property ID: P527
  value: Leukemia inhibitory factor /oncostatin, conserved site
additional property: PropertyValue
  property ID: P637
  value: NP_001244064
additional property: PropertyValue
  property ID: P637
  value: NP_002300
additional property: PropertyValue
  property ID: P637
  value: XP_024308007
additional property: PropertyValue
  property ID: P638
  value: 1EMR
additional property: PropertyValue
  property ID: P638
  value: 1PVH
additional property: PropertyValue
  property ID: P638
  value: 2Q7N
additional property: PropertyValue
  property ID: P646
  value: /m/096sp9
additional property: PropertyValue
  property ID: P680
  value: signaling receptor binding
additional property: PropertyValue
  property ID: P680
  value: growth factor activity
additional property: PropertyValue
  property ID: P680
  value: cytokine activity
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P682
  value: negative regulation of cell population proliferation
additional property: PropertyValue
  property ID: P682
  value: stem cell differentiation
additional property: PropertyValue
  property ID: P682
  value: positive regulation of peptidyl-serine phosphorylation of STAT protein
additional property: PropertyValue
  property ID: P692
  value: PBB GE LIF 205266 at fs.png
additional property: PropertyValue
  property ID: P702
  value: LIF
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000249075
additional property: PropertyValue
  property ID: P705
  value: ENSP00000384450
additional property: PropertyValue
  property ID: P1417
  value: topic/leukemia-inhibitory-factor
additional property: PropertyValue
  property ID: P6366
  value: 27284151
confidence:
  popularity graph score:
    score: 0.014
    score pct: 1
    tier: established
    components:
      sitelinks: 13
      sitelinks norm: 0.031
      unique citations: 23
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 13
  unique citations: 23
  monthly pageviews: 0
  yearly pageviews: 122
  pageview trend:
    m: 2026-06
    v: 68
  pageview trend:
    m: 2026-05
    v: 3
  pageview trend:
    m: 2026-05
    v: 10
  pageview trend:
    m: 2026-05
    v: 3
  pageview trend:
    m: 2026-05
    v: 1
  pageview trend:
    m: 2026-04
    v: 35
  pageview trend:
    m: 2026-04
    v: 2
  popularity:
    sitelinks: 13
    max: 423
    pct: 3.1
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P15018
    source count: 1
    confidence: 0.2
  P361:
    value: Q24724363
    source count: 1
    confidence: 0.2
    value label: four-helical cytokine-like, core
  P361:
    value: Q24723759
    source count: 1
    confidence: 0.2
    value label: Leukemia inhibitory factor
  P361:
    value: Q95352248
    source count: 1
    confidence: 0.2
    value label: Leukemia inhibitory factor /oncostatin, conserved site, protein family
  P373:
    value: Leukemia inhibitory factor (LIF)
    source count: 0
    confidence: 0.0
  P527:
    value: Q24781563
    source count: 1
    confidence: 0.2
    value label: Leukemia inhibitory factor /oncostatin, conserved site
  P637:
    value: NP_001244064
    source count: 1
    confidence: 0.2
  P637:
    value: NP_002300
    source count: 1
    confidence: 0.2
  P637:
    value: XP_024308007
    source count: 1
    confidence: 0.2
  P637:
    value: XP_024308008
    source count: 1
    confidence: 0.2
  P638:
    value: 1EMR
    source count: 1
    confidence: 0.2
  P638:
    value: 1PVH
    source count: 1
    confidence: 0.2

value: 2Q7N
source count: 1
confidence: 0.2

value: /m/096sp9
source count: 0
confidence: 0.0

value: Q14819233
source count: 1
confidence: 0.2
value label: signaling receptor binding

value: Q14820601
source count: 5
confidence: 1.0
value label: growth factor activity

value: Q14862699
source count: 5
confidence: 1.0
value label: cytokine activity

value: Q167149
source count: 2
confidence: 0.4
value label: protein binding

value: Q14878781
source count: 3
confidence: 0.6
value label: leukemia inhibitory factor receptor binding

value: Q14645596
source count: 3
confidence: 0.6
value label: extracellular region

value: Q1385443
source count: 3
confidence: 0.6
value label: extracellular space

value: Q220599
source count: 1
confidence: 0.2
value label: cytosol

value: Q1385443
source count: 3
confidence: 0.6
value label: extracellular space

value: Q14599399
source count: 1
confidence: 0.2
value label: negative regulation of cell population proliferation

value: Q14864672
source count: 1
confidence: 0.2
value label: stem cell differentiation

value: Q14878782
source count: 1
confidence: 0.2
value label: positive regulation of peptidyl-serine phosphorylation of STAT protein

value: Q14758936
source count: 1
confidence: 0.2
value label: positive regulation of MAPK cascade

value: Q14820663
source count: 1
confidence: 0.2
value label: positive regulation of peptidyl-serine phosphorylation

value: PBB GE LIF 205266 at fs.png
source count: 0
confidence: 0.0

value: Q14878795
source count: 1
confidence: 0.2
value label: LIF

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000249075
source count: 1
confidence: 0.2

value: ENSP00000384450
source count: 1
confidence: 0.2

value: topic/leukemia-inhibitory-factor
source count: 0
confidence: 0.0

value: 27284151
source count: 0
confidence: 0.0

value: C27284151
source count: 1
confidence: 0.2

source: Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation
stated in qid: Q24313382
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-02-27

source: Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction
stated in qid: Q24336395
retrieved: 2018-02-27

source: Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation
stated in qid: Q24313382
retrieved: 2018-02-27

source: Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF
stated in qid: Q24297991
retrieved: 2018-02-27

source: The Sin3a repressor complex is a master regulator of STAT transcriptional activity
stated in qid: Q24292983
retrieved: 2018-02-27

source: Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130
stated in qid: Q27642282
retrieved: 2019-04-08

source: The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling
stated in qid: Q28119167
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction
stated in qid: Q24336395
retrieved: 2019-04-08

source: The Sin3a repressor complex is a master regulator of STAT transcriptional activity
stated in qid: Q24292983
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF
stated in qid: Q24297991
retrieved: 2019-04-08

source: STAT1 activation regulates proliferation and differentiation of renal progenitors
stated in qid: Q24338667
retrieved: 2019-04-08

source: Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells
stated in qid: Q24305084
retrieved: 2019-04-08

source: Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells
stated in qid: Q24296832
retrieved: 2019-04-08

source: Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer
stated in qid: Q24314480
retrieved: 2019-04-08

source: Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells
stated in qid: Q24296832
retrieved: 2018-02-27

source: OpenAlex
stated in qid: Q107507571
retrieved: 2022-01-26

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q6534502
domain: protein
level: standard
html url: https://4ort.xyz/entity/lif-interleukin-6-family-cytokine
markdown url: https://4ort.xyz/entity/lif-interleukin-6-family-cytokine.md
facts url summary: https://4ort.xyz/entity/lif-interleukin-6-family-cytokine/facts.json
facts url standard: https://4ort.xyz/entity/lif-interleukin-6-family-cytokine/facts.json
facts url full: https://4ort.xyz/entity/lif-interleukin-6-family-cytokine/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T07:42:17.465759Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-04-10T23:44:43.472459+00:00Z