# Leucine rich repeat kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q409961](https://www.wikidata.org/wiki/Q409961)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/LRRK2)  
**Source**: https://4ort.xyz/entity/leucine-rich-repeat-kinase-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q5S007)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
6. [LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
7. [LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
8. [The regulation and deregulation of Wnt signaling by PARK genes in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
10. [The R1441C mutation of LRRK2 disrupts GTP hydrolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
11. [Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
12. [Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
13. [Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
14. [LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
15. [The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
16. [Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
17. [Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
18. [Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
19. [Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
20. [LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
21. [Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
22. [GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
23. [Dominant-negative effects of LRRK2 heterodimers: A possible mechanism of neurodegeneration in Parkinson’s disease caused by LRRK2 I2020T mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
24. [Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
25. [The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
26. [GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
27. [Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
28. [Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
29. [A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
30. [Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
31. [ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
32. [LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007)
33. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007)
34. [Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007)
35. [LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007)
36. [Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007)
37. [ArfGAP1 Is a GTPase Activating Protein for LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007)
38. [ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007)
39. [Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007)
40. [LRRK2 Kinase Regulates Synaptic Morphology through Distinct Substrates at the Presynaptic and Postsynaptic Compartments of theDrosophilaNeuromuscular Junction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
41. [Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
42. [Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
43. [The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
44. [Kinase activity of mutant LRRK2 mediates neuronal toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
45. [GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
46. [Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
47. [LRRK2 Promotes Tau Accumulation, Aggregation and Release.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
48. [Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
49. [Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)
50. [LRRK2 and the Stress Response: Interaction with MKKs and JNK-Interacting Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007)