# Leucine-rich repeat kinase 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q15331171](https://www.wikidata.org/wiki/Q15331171)  
**Source**: https://4ort.xyz/entity/leucine-rich-repeat-kinase-2-q15331171


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q5S006)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
5. [Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
6. [LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
7. [LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006)
9. [Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
10. [Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
11. [Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
12. [Kinase activity of mutant LRRK2 mediates neuronal toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
13. [Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
14. [Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
15. [RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
16. [ArfGAP1 Is a GTPase Activating Protein for LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
17. [Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
18. [GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
19. [Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
20. [Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
21. [LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
22. [Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
23. [A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
24. [ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
25. [Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006)
26. [Localization of LRRK2 to membranous and vesicular structures in mammalian brain](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006)
27. [Leucine-rich repeat kinase 2 associates with lipid rafts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
28. [Localization of LRRK2 to membranous and vesicular structures in mammalian brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
29. [Leucine-rich repeat kinase 2 associates with lipid rafts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
31. [Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
32. [LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
33. [LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006)
34. [LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006)
35. [Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006)
36. ensembl Release 106