# Leucine-rich repeat-containing G protein-coupled receptor 4

> mammalian protein found in Mus musculus

**Wikidata**: [Q21984626](https://www.wikidata.org/wiki/Q21984626)  
**Source**: https://4ort.xyz/entity/leucine-rich-repeat-containing-g-protein-coupled-receptor-4-q21984626


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/A2ARI4)
3. Q20641742
4. [R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=A2ARI4&geneProductId=UniProtKB:A2ARI4)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
8. [Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
9. [Regulation of bone formation and remodeling by G-protein-coupled receptor 48](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
10. [Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
11. [Defective postnatal development of the male reproductive tract in LGR4 knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
12. [Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
13. [Lgr4 Gene Deficiency Increases Susceptibility and Severity of Dextran Sodium Sulfate-induced Inflammatory Bowel Disease in Mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
14. [LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
15. [Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
16. [Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4)
17. ensembl Release 106