# Leptin

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28560385](https://www.wikidata.org/wiki/Q28560385)  
**Source**: https://4ort.xyz/entity/leptin-q28560385


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P50596)
3. Q20641742
4. [Evidence indicating that renal tubular metabolism of leptin is mediated by megalin but not by the leptin receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
5. [Specific increase in leptin production in obese (falfa) rat adipose cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
7. [A short form of leptin receptor performs signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
9. [Obesity reduces bone density associated with activation of PPARγ and suppression of Wnt/β-catenin in rapidly growing male rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
10. [Hypothalamic CART is a new anorectic peptide regulated by leptin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
11. [Inhibitory effect of leptin on the rat ovary during the ovulatory process](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
12. [Rat heart is a site of leptin production and action](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
13. [Leptin modulates cell morphology and cytokine release in microglia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
14. [Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
15. [Leptin induces hypertrophy through activating the peroxisome proliferator‐activated receptor α pathway in cultured neonatal rat cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
16. [Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
17. [Leptin Induces Nitric Oxide-Mediated Inhibition of Lipolysis and Glyceroneogenesis in Rat White Adipose Tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
18. [Leptin regulates proinflammatory immune responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
19. [A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
20. [Hyperphagia and central mechanisms for leptin resistance during pregnancy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
21. [A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
22. [Circadian profile of peripheral hormone levels in Sprague-Dawley rats and in common marmosets (Callithrix jacchus).](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
23. [Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
24. [Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
25. [Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
26. [Injections of leptin into rat ventromedial hypothalamus increase adipocyte apoptosis in peripheral fat and in bone marrow](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
27. [Intracellular signalling. Key enzyme in leptin-induced anorexia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
28. [Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
29. [Evidence from the aged orchidectomized male rat model that 17beta-estradiol is a more effective bone-sparing and anabolic agent than 5alpha-dihydrotestosterone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
30. [Vitamin E regulates adipocytokine expression in a rat model of dietary-induced obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
31. [Leptin Receptor Signal Transduction: OBRa and OBRb offaType](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
32. [The effect of leptin on the tonic secretion of gonadotropins in the female rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
33. [Leptin administration affects growth and skeletal development in a rat intrauterine growth restriction model: preliminary study](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
34. [Leptin affects intestinal epithelial cell turnover in correlation with leptin receptor expression along the villus-crypt axis after massive small bowel resection in a rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
35. [Apical leptin induces chloride secretion by intestinal epithelial cells and in a rat model of acute chemotherapy-induced colitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
36. [Regular exercise limits alcohol effects on trabecular, cortical thickness and porosity, and osteocyte apoptosis in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
37. [Leptin augments cerebral hemodynamic reserve after three-vessel occlusion: distinct effects on cerebrovascular tone and proliferation in a nonlethal model of hypoperfused rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
38. [Basal, endogenous leptin is metabolically active in newborn rat pups](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
39. [Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
40. [Leptin induces an inflammatory phenotype in lean Wistar rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
41. [Leptin plays a catabolic role on articular cartilage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
42. [Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
43. [Short term 13-cis-retinoic acid treatment at therapeutic doses elevates expression of leptin, GLUT4, PPARgamma and aP2 in rat adipose tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
44. [Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
45. [Luminal leptin inhibits L-glutamine transport in rat small intestine: involvement of ASCT2 and B0AT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
46. [Curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50596)
47. ensembl Release 106