# Leptin

> mammalian protein found in Mus musculus

**Wikidata**: [Q22695891](https://www.wikidata.org/wiki/Q22695891)  
**Source**: https://4ort.xyz/entity/leptin-q22695891


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P41160)
3. Q20641742
4. [The leptin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
5. [Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
8. [Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160)
10. [Endocrine regulation of energy metabolism by the skeleton](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160)
11. [C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160)
12. [Role of the fatty acid binding protein mal1 in obesity and insulin resistance](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160)
13. [Hypothalamic CART is a new anorectic peptide regulated by leptin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160)
14. [Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160)
15. [C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
16. [Role of the fatty acid binding protein mal1 in obesity and insulin resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
17. [Endocrine regulation of energy metabolism by the skeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
18. [Hypothalamic CART is a new anorectic peptide regulated by leptin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
19. [Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
20. [Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160)
21. [Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
22. [Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
23. [NMDA and AMPA glutamate receptor subtypes in the thoracic spinal cord in lean and obese-diabetic ob/ob mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
24. [Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
25. [Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
26. [Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
27. [Leptin regulates proinflammatory immune responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
28. [VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
29. [Mex3c mutation reduces adiposity and increases energy expenditure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
30. [VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160)
31. [SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
32. [Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
33. [Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
34. [Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
35. [In vivo modulation of Hmgic reduces obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
36. [Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
37. [Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160)
38. [Dopamine is required for hyperphagia in Lep(ob/ob) mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
39. [Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160)
40. [Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
41. [SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160)
42. [Leptin modulates autophagy in human CD4+CD25- conventional T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
43. [Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
44. [VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
45. [Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
46. [Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
47. [Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
48. [Increased Aortic Stiffness and Attenuated Lysyl Oxidase Activity in Obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160)
49. ensembl Release 106