# Lee Hartwell > American biologist **Wikidata**: [Q295869](https://www.wikidata.org/wiki/Q295869) **Wikipedia**: [English](https://en.wikipedia.org/wiki/Leland_H._Hartwell) **Source**: https://4ort.xyz/entity/lee-hartwell ## Summary Lee Hartwell is an American biologist renowned for his groundbreaking contributions to the field of cell cycle regulation, particularly through his research on genetic mechanisms that control cell division. He was awarded the 2001 Nobel Prize in Physiology or Medicine for his discoveries. His work has had a profound impact on cancer biology and therapeutic development. ## Biography - Born: October 30, 1939 - Nationality: United States - Education: California Institute of Technology (Ph.D. in Biology, 1963); Massachusetts Institute of Technology (Postdoctoral research) - Known for: Discovering genetic mechanisms that regulate the cell cycle, particularly the START checkpoint in yeast cells - Employer(s): University of Washington, Arizona State University, University of California, Irvine, California Institute of Technology, Massachusetts Institute of Technology - Field(s): Cell biology, genetics, biochemistry, molecular biology ## Contributions Lee Hartwell is best known for identifying critical genetic regulators of the cell cycle, particularly in yeast, which laid the foundation for understanding how cells divide and grow. His work led to the discovery of checkpoint mechanisms that control the cell cycle, which are essential for understanding cancer development and treatment. He identified the START checkpoint in yeast, which controls the transition from G1 to S phase. His research has been instrumental in advancing the field of cancer biology by identifying how disruptions in the cell cycle contribute to tumor development. Hartwell's work has also contributed to the development of targeted cancer therapies and improved understanding of cellular regulation. ## FAQs ### What is Lee Hartwell known for? Lee Hartwell is known for his pioneering research on the genetic regulation of the cell cycle, particularly in yeast, which earned him the 2001 Nobel Prize in Physiology or Medicine. His work identified key mechanisms that control cell division and has had a major impact on cancer research. ### Where has Lee Hartwell worked? Hartwell has held positions at the University of Washington, Arizona State University, University of California, Irvine, California Institute of Technology, and Massachusetts Institute of Technology. He has also been affiliated with institutions like the Fred Hutchinson Cancer Research Center. ### What awards has Lee Hartwell received? Hartwell has received numerous awards including the Nobel Prize in Physiology or Medicine (2001), the Albert Lasker Award for Basic Medical Research, the Canada Gairdner International Award, and the Louisa Gross Horwitz Prize, among others. ### What is the significance of Hartwell's START model? The START model, developed by Hartwell, explains how yeast cells initiate DNA synthesis and cell division. It has become a foundational concept in cell cycle research and has informed understanding of similar mechanisms in higher organisms, including humans. ### How has Lee Hartwell influenced cancer research? Hartwell's research on cell cycle checkpoints has been crucial to understanding how cells regulate growth and division. His work has informed the development of cancer therapies that target dysregulated cell cycle mechanisms, making it possible to design treatments that halt or slow tumor growth. ## Why They Matter Lee Hartwell's work fundamentally changed how scientists understand cellular regulation and cancer. His identification of the START checkpoint and other genetic regulators has provided the foundation for modern cancer research. His findings have enabled the development of targeted therapies that exploit the same mechanisms he uncovered. Without his contributions, the field of cell biology would lack critical insights into how cells divide and how that process can go awry in cancer. Hartwell's influence extends beyond the lab into clinical oncology, where his research has helped guide the development of drugs that target specific cell cycle pathways. His work continues to be cited and built upon, influencing new generations of scientists and therapeutic strategies. ## Notable For - Nobel Prize in Physiology or Medicine (2001) for discoveries in cell cycle regulation - Development of the START model for yeast cell cycle control - Pioneering use of yeast genetics to understand cell cycle regulation - Leadership roles at the Fred Hutchinson Cancer Research Center - Contributions to understanding the genetic basis of cancer - Mentorship of numerous researchers in the field of cell biology - Authorship of foundational papers in cell cycle research ## Body ### Early Life and Education Lee Hartwell was born on October 30, 1939, in the United States. He pursued his undergraduate and graduate education with a focus on biology and chemistry, earning his Ph.D. from the California Institute of Technology in 1963. His early academic training laid the foundation for his later groundbreaking research in cell cycle regulation. ### Career Hartwell's career spans several prestigious institutions. He began his independent research career at the University of Washington, where he focused on yeast genetics. He later moved to Arizona State University and then to the University of California, Irvine, where he continued his work on cell cycle regulation. His research during this period was instrumental in identifying key genetic mechanisms that control cell division. ### Major Discoveries Hartwell's most significant discovery was the identification of the START checkpoint in yeast, which controls the transition from G1 to S phase of the cell cycle. This discovery was foundational in understanding how cells regulate growth and division. His work revealed that mutations in certain genes could lead to uncontrolled cell division, a hallmark of cancer. He also identified other key regulatory mechanisms that ensure proper cell cycle progression, including the role of environmental signals in triggering cell cycle checkpoints. ### Awards and Recognition Hartwell received the 2001 Nobel Prize in Physiology or Medicine for his discoveries in cell cycle regulation. He was also awarded the Albert Lasker Award for Basic Medical Research, the Canada Gairdner International Award, and the Louisa Gross Horwitz Prize, among others. These awards recognized his significant contributions to the understanding of cellular regulation and cancer biology. ### Research Impact Hartwell's research has had a lasting impact on the field of cell biology and cancer research. His work on cell cycle checkpoints has informed the development of targeted cancer therapies. By identifying the genetic mechanisms that control cell division, he provided the scientific community with tools to understand and treat cancer more effectively. His findings have been cited in thousands of research papers and have influenced the direction of cancer research for decades. ### Legacy and Influence Hartwell's influence extends beyond his own research. He has mentored numerous researchers who have gone on to make significant contributions to the field. His work continues to be foundational in the study of cell cycle regulation and cancer biology. The principles he established are still used today in the development of new cancer therapies and in understanding how cells regulate growth and division. His legacy is evident in the ongoing research into targeted cancer treatments and the development of drugs that exploit the same mechanisms he uncovered. ### Institutional Affiliations Hartwell has been affiliated with several institutions throughout his career, including the University of Washington, Arizona State University, University of California, Irvine, California Institute of Technology, and Massachusetts Institute of Technology. His collaborative work with these institutions has led to significant advances in the field of cell biology and cancer research. ### Publications and Research Hartwell's research has been published in leading scientific journals and has contributed to the understanding of cell cycle regulation. His work on yeast genetics provided a model for understanding similar mechanisms in human cells. His publications have been foundational in the field and continue to be cited by researchers studying cell division and cancer. ### Awards and Honors Hartwell received the Nobel Prize in Physiology or Medicine in 2001 for his discoveries in cell cycle regulation. He also received the Albert Lasker Award for Basic Medical Research, the Canada Gairdner International Award, and the Louisa Gross Horwitz Prize. These awards recognized his significant contributions to the field of cell biology and cancer research. ### Mentorship and Education Hartwell has mentored numerous researchers who have gone on to make significant contributions to the field. His mentorship has influenced the direction of cancer research and has helped to train new generations of scientists in the field of cell biology. ### Ongoing Influence Hartwell's work continues to be foundational in the study of cell cycle regulation and cancer biology. His principles are still used today in the development of new cancer therapies and in understanding how cells regulate growth and division. His influence is evident in the ongoing research into targeted cancer treatments and the development of drugs that exploit the same mechanisms he uncovered. ## References 1. [1998 Winners. Lasker Foundation](http://www.laskerfoundation.org/awards/1998basic.htm) 2. [The Nobel Prize in Physiology or Medicine 2001. nobelprize.org](https://www.nobelprize.org/prizes/medicine/2001/summary/) 3. [Table showing prize amounts. Nobel Foundation. 2019](https://www.nobelprize.org/uploads/2019/04/prize-amounts-2020.pdf) 4. [Source](https://www.cuimc.columbia.edu/research/louisa-gross-horwitz-prize/horwitz-prize-awardees/2000-1991-awardees) 5. [GM Cancer Previous Prize Winners](http://www.gm.com/company/gmability/philanthropy/cancer_research/prize.htm) 6. [Source](https://www.brandeis.edu/rosenstiel/rosenstiel-award/past.html) 7. [Source](https://genetics.org.uk/medals-and-prizes/genetics-society-medals-and-lectures/mendel-medal/) 8. International Standard Name Identifier 9. Virtual International Authority File 10. CiNii Research 11. SNAC 12. Encyclopædia Britannica Online 13. Brockhaus Enzyklopädie 14. Munzinger Personen 15. Freebase Data Dumps. 2013 16. LIBRIS. 2011 17. National Library of Israel Names and Subjects Authority File