# LDL receptor related protein 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21132095](https://www.wikidata.org/wiki/Q21132095)  
**Source**: https://4ort.xyz/entity/ldl-receptor-related-protein-6


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O75581)
3. Q20641742
4. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
5. [A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
6. [The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
7. [LDL-receptor-related proteins in Wnt signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
8. [The importance of Wnt signalling for neurodegeneration in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
9. [Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
11. [Evidence against a human cell-specific role for LRP6 in anthrax toxin entry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
12. [The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
13. [Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
14. [Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
15. [Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2to LRP6 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
16. [ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
17. [Cell cycle control of wnt receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
18. [The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
19. [LDL-receptor-related protein 6 is a receptor for Dickkopf proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
20. [Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
21. [Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
22. [Structural Studies of Wnts and Identification of an LRP6 Binding Site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
23. [Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
24. [SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
25. [IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
26. [Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
27. [Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
28. [LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
29. [Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
30. [Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
31. [Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
32. [Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
33. [Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
34. [Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
35. [Crystal structures of the extracellular domain of LRP6 and its complex with DKK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
36. [Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
37. [R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
38. [Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
39. [LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
40. [The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
41. [Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
42. [Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
43. [The regulation and deregulation of Wnt signaling by PARK genes in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
44. [Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
45. [LDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
46. [Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
47. [Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
48. [Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
49. [The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)
50. [Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581)