# LDL receptor related protein 5

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111886](https://www.wikidata.org/wiki/Q21111886)  
**Source**: https://4ort.xyz/entity/ldl-receptor-related-protein-5-q21111886


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O75197)
3. Q20641742
4. [Evidence against a human cell-specific role for LRP6 in anthrax toxin entry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
5. [Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
6. [Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
7. [Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
8. [APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
9. [Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
10. [SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75197&geneProductId=UniProtKB:O75197)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75197&geneProductId=UniProtKB:O75197)
13. [Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
14. [The importance of Wnt signalling for neurodegeneration in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
15. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
16. [Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
17. [The importance of Wnt signalling for neurodegeneration in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
20. [LRP5 variants may contribute to ADPKD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
21. [Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
22. [The regulation and deregulation of Wnt signaling by PARK genes in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
23. [Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
24. [Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
25. [Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
26. [Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
27. [An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
28. [Low-density lipoprotein receptor-related protein 5 polymorphisms are associated with bone mineral density in Greek postmenopausal women: an interaction with calcium intake](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
29. [Association of LPR5 polymorphism with bone mass density and cholesterol level in population of Chinese Han](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
30. [Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
31. [Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
32. [LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
33. [Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
34. [Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
35. [LDL-receptor-related proteins in Wnt signal transduction](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
36. [Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
37. [Molecular Cloning and Characterization of LR3, a Novel LDL Receptor Family Protein with Mitogenic Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
38. [Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5.](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
39. [Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
40. [A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
41. [Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
42. [Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
43. [LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O75197)
44. [Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
45. [Association of LPR5 polymorphism with bone mass density and cholesterol level in population of Chinese Han](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
46. [Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
47. [Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
48. [An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
49. [Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)
50. [A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75197)