# LDL receptor related protein 2

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28560913](https://www.wikidata.org/wiki/Q28560913)  
**Source**: https://4ort.xyz/entity/ldl-receptor-related-protein-2-q28560913


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P98158)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
5. [Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
6. [Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
7. [Megalin-mediated endocytosis of cystatin C in proximal tubule cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
8. [Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
9. [Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
10. [Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
11. [Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
12. [The Adaptor Protein ARH Escorts Megalin to and through Endosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
13. [Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
14. [Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
15. [Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
16. [Evidence indicating that renal tubular metabolism of leptin is mediated by megalin but not by the leptin receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
17. [Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
18. [The interaction between megalin and ClC-5 is scaffolded by the Na⁺-H⁺ exchanger regulatory factor 2 (NHERF2) in proximal tubule cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
19. [Soluble megalin is accumulated in the lumen of the rat endolymphatic sac](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
20. [Age-related change of endocytic receptors megalin and cubilin in the kidney in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
21. [GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
22. [Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
23. [Cubilin and megalin co-localize in the neonatal inner ear.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
24. [Identification of an apical sorting determinant in the cytoplasmic tail of megalin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
25. [Proximal tubule Na transporter responses are the same during acute and chronic hypertension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
26. [The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
27. [Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
28. [The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
29. [Megalin is a receptor for albumin in astrocytes and is required for the synthesis of the neurotrophic factor oleic acid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
30. [Epithelial trafficking of Sonic hedgehog by megalin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
31. [Megalin mediates the transport of leptin across the blood-CSF barrier.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
32. [Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
33. [Megalin functions as an endocytic sonic hedgehog receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
34. [Megalin binds and internalizes angiotensin II.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
35. [Megalin binds and internalizes angiotensin-(1-7).](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
36. [Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
37. [Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
38. [Gentamicin inhibits rat renal cortical homotypic endosomal fusion: role of megalin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
39. [Megalin mediates renal uptake of heavy metal metallothionein complexes.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
40. [Modulation of gene expression by moxonidine in rats with chronic renal failure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
41. [Regulation of gp330/megalin expression by vitamins A and D](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
42. [Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98158)
43. ensembl Release 106