# LDL receptor related protein 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111528](https://www.wikidata.org/wiki/Q21111528)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/LRP1)  
**Source**: https://4ort.xyz/entity/ldl-receptor-related-protein-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q07954)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
5. [Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
6. [The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
7. [Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q07954)
8. [Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
9. [LDL receptor-related protein as a component of the midkine receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
10. [Phosphorylation of LRP1 regulates the interaction with Fe65](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
11. [HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
12. [Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
13. [CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
14. [Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
15. [Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
16. [Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
17. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q07954)
18. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
19. [Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
20. [Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
21. [Whole exome sequencing identifies LRP1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
22. [Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
23. [Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
24. [LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid-β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
25. [Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
26. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q07954)
27. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q07954)
28. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
29. [The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
30. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q07954)
31. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
32. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
33. [Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
34. [SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q07954)
35. [Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
36. [Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
37. [SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
38. [Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07954)
39. Ensembl Release 99
40. UMLS 2023
41. Transporter Classification database
42. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)