# LCK proto-oncogene, Src family tyrosine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q9020944](https://www.wikidata.org/wiki/Q9020944)  
**Source**: https://4ort.xyz/entity/lck-proto-oncogene-src-family-tyrosine-kinase-q9020944


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P06239)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
6. [Interaction of p56lck with CD4 in the yeast two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
7. [The influence of SRC-family tyrosine kinases on Na,K-ATPase activity in lens epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239)
9. [p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239)
10. [Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239)
11. [The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
12. [The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
13. [Molecular basis for regulation of Src by the docking protein p130Cas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
14. [BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
15. [ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
16. [Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappa B, and serine and tyrosine phosphorylation of Ikappa B-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
17. [PKD2 interacts with Lck and regulates NFAT activity in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
18. [Unc119, a novel activator of Lck/Fyn, is essential for T cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
19. [Human Homologue of the Drosophila Discs Large Tumor Suppressor Binds to p56 Tyrosine Kinase and Shaker Type Kv1.3 Potassium Channel in T Lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
20. [Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
21. [Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
22. [Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
23. [p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
24. [Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
25. [Characterization of Lck-binding elements in the herpesviral regulatory Tip protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
26. [SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
27. [Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
28. [Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
29. [A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
30. [Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
31. [A proline to glycine mutation in the Lck SH3-domain affects conformational sampling and increases ligand binding affinity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
32. [Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
33. [Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
34. [Identification of substrates of human protein-tyrosine phosphatase PTPN22](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
35. [Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
36. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
37. [Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
38. [Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
39. [Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
40. [Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
41. [Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
42. [Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
43. [GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
44. [Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
45. [Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
46. [Large-scale structural analysis of the classical human protein tyrosine phosphatome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
47. [Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
48. [Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
49. [Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)
50. [The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239)