# Large tumor suppressor kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21114061](https://www.wikidata.org/wiki/Q21114061)  
**Source**: https://4ort.xyz/entity/large-tumor-suppressor-kinase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O95835)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
5. [Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
6. [Tumor suppressor LATS1 is a negative regulator of oncogene YAP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
7. [DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
8. [Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
9. [Molecular characterization of human homologs of yeast MOB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
10. [The Hippo pathway regulates Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
11. [AMPK modulates Hippo pathway activity to regulate energy homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
12. [Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
13. [Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
14. [Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
15. [Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
16. [Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
17. [A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
18. [Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
19. [Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
20. [Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
21. [Regulation of ploidy and senescence by the AMPK-related kinase NUAK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
22. [RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
23. [The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
24. [LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
25. [Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
26. [A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835)
28. [A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835)
29. [The Hippo pathway regulates Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835)
30. [The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
31. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
32. [Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835)
33. Ensembl Release 99