Lactate dehydrogenase A
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P00338
additional property: PropertyValue
  property ID: P361
  value: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
additional property: PropertyValue
  property ID: P361
  value: NAD(P)-binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: L-lactate dehydrogenase
additional property: PropertyValue
  property ID: P527
  value: L-lactate dehydrogenase, active site
additional property: PropertyValue
  property ID: P527
  value: Lactate/malate dehydrogenase, N-terminal
additional property: PropertyValue
  property ID: P527
  value: Lactate/malate dehydrogenase, C-terminal
additional property: PropertyValue
  property ID: P637
  value: NP_001128711
additional property: PropertyValue
  property ID: P637
  value: NP_001158886
additional property: PropertyValue
  property ID: P637
  value: NP_001158887
additional property: PropertyValue
  property ID: P638
  value: 1I10
additional property: PropertyValue
  property ID: P638
  value: 4AJP
additional property: PropertyValue
  property ID: P638
  value: 4JNK
additional property: PropertyValue
  property ID: P680
  value: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
additional property: PropertyValue
  property ID: P680
  value: NAD binding
additional property: PropertyValue
  property ID: P680
  value: lactate dehydrogenase activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: extracellular exosome
additional property: PropertyValue
  property ID: P682
  value: post-embryonic animal organ development
additional property: PropertyValue
  property ID: P682
  value: lactate metabolic process
additional property: PropertyValue
  property ID: P682
  value: response to hypoxia
additional property: PropertyValue
  property ID: P702
  value: LDHA
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000227157
additional property: PropertyValue
  property ID: P705
  value: ENSP00000368722
additional property: PropertyValue
  property ID: P705
  value: ENSP00000379524
confidence:
  popularity graph score:
    score: 0.004
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 30
      unique citations norm: 0.012
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 30
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P00338
    source count: 1
    confidence: 0.2
  P361:
    value: Q24726404
    source count: 1
    confidence: 0.2
    value label: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
  P361:
    value: Q41797412
    source count: 1
    confidence: 0.2
    value label: NAD(P)-binding domain superfamily
  P361:
    value: Q409464
    source count: 1
    confidence: 0.2
    value label: L-lactate dehydrogenase
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83163289
    source count: 1
    confidence: 0.2
    value label: Lactate/malate dehydrogenase, C-terminal domain, protein family
  P527:
    value: Q24778968
    source count: 1
    confidence: 0.2
    value label: L-lactate dehydrogenase, active site
  P527:
    value: Q24745122
    source count: 1
    confidence: 0.2
    value label: Lactate/malate dehydrogenase, N-terminal
  P527:
    value: Q24782919
    source count: 1
    confidence: 0.2
    value label: Lactate/malate dehydrogenase, C-terminal
  P637:
    value: NP_001128711
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001158886
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001158887
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001158888
    source count: 1
    confidence: 0.2
  P637:
    value: NP_005557
    source count: 1
    confidence: 0.2
  P638:
    value: 1I10
    source count: 1
    confidence: 0.2
  P638:
    value: 4AJP
    source count: 1
    confidence: 0.2
  P638:
    value: 4JNK
    source count: 1
    confidence: 0.2
  P638:
    value: 4L4R
    source count: 1
    confidence: 0.2
  P638:
    value: 4L4S
    source count: 1
    confidence: 0.2
  P680:
    value: Q14864141
    source count: 1
    confidence: 0.2
    value label: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
  P680:
    value: Q14890060
    source count: 1
    confidence: 0.2
    value label: NAD binding

value: Q21761224
source count: 1
confidence: 0.2
value label: lactate dehydrogenase activity

value: Q14864244
source count: 1
confidence: 0.2
value label: kinase binding

value: Q167149
source count: 1
confidence: 0.2
value label: protein binding

value: Q79899
source count: 2
confidence: 0.4
value label: cytoplasm

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q903634
source count: 5
confidence: 1.0
value label: extracellular exosome

value: Q40260
source count: 1
confidence: 0.2
value label: nucleus

value: Q220599
source count: 2
confidence: 0.4
value label: cytosol

value: Q21133144
source count: 1
confidence: 0.2
value label: post-embryonic animal organ development

value: Q15317356
source count: 1
confidence: 0.2
value label: lactate metabolic process

value: Q14819239
source count: 1
confidence: 0.2
value label: response to hypoxia

value: Q162643
source count: 1
confidence: 0.2
value label: glycolytic process

value: Q14820916
source count: 1
confidence: 0.2
value label: response to organic cyclic compound

value: Q18028499
source count: 1
confidence: 0.2
value label: LDHA

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000227157
source count: 1
confidence: 0.2

value: ENSP00000368722
source count: 1
confidence: 0.2

value: ENSP00000379524
source count: 1
confidence: 0.2

value: ENSP00000395337
source count: 1
confidence: 0.2

value: ENSP00000406172
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer
stated in qid: Q24337240
retrieved: 2019-04-08

source: Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency
stated in qid: Q28115226
retrieved: 2018-01-01

source: Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining
stated in qid: Q24338753
retrieved: 2018-01-01

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase
stated in qid: Q27630848
retrieved: 2018-01-01

source: Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli
stated in qid: Q28118514
retrieved: 2018-01-01

source: E-cadherin interactome complexity and robustness resolved by quantitative proteomics
stated in qid: Q28115399
retrieved: 2017-09-26

source: E-cadherin interactome complexity and robustness resolved by quantitative proteomics
stated in qid: Q28115399
retrieved: 2019-04-08

source: Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency
stated in qid: Q28115226
retrieved: 2019-04-08

source: Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining
stated in qid: Q24338753
retrieved: 2019-04-08

source: Defining the membrane proteome of NK cells
stated in qid: Q24323157
retrieved: 2017-09-26

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2017-09-26

source: Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
stated in qid: Q24313258
retrieved: 2017-09-26

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2017-09-26

source: Intestinal epithelial cells secrete exosome-like vesicles
stated in qid: Q24291534
retrieved: 2017-09-26

source: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
stated in qid: Q24311780
retrieved: 2017-09-26

source: Proteomic characterization of the human sperm nucleus
stated in qid: Q24305129
retrieved: 2017-09-26

source: Centrosomal proteins and lactate dehydrogenase possess a common epitope in human cell lines
stated in qid: Q24616499
retrieved: 2019-04-08

source: Proteomic characterization of the human sperm nucleus
stated in qid: Q24305129
retrieved: 2019-04-08

source: Defining the membrane proteome of NK cells
stated in qid: Q24323157
retrieved: 2019-04-08

source: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
stated in qid: Q24311780
retrieved: 2019-04-08

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2019-04-08

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2019-04-08

source: Intestinal epithelial cells secrete exosome-like vesicles
stated in qid: Q24291534
retrieved: 2019-04-08

source: Quantitative Proteomic Analysis of Human Substantia Nigra in Alzheimer’s Disease, Huntington’s Disease and Multiple Sclerosis
stated in qid: Q24297593
retrieved: 2017-09-26

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2018-12-05

source: Q20641742
stated in qid: Q20641742
retrieved: 2018-12-07

source: ensembl Release 96
stated in qid: Q63170780

wikidata id: Q21133145
domain: protein
level: standard
html url: https://4ort.xyz/entity/lactate-dehydrogenase-a
markdown url: https://4ort.xyz/entity/lactate-dehydrogenase-a.md
facts url summary: https://4ort.xyz/entity/lactate-dehydrogenase-a/facts.json
facts url standard: https://4ort.xyz/entity/lactate-dehydrogenase-a/facts.json
facts url full: https://4ort.xyz/entity/lactate-dehydrogenase-a/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-18T08:20:49.872021Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:50.900290+00:00Z