# KIT proto-oncogene, receptor tyrosine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q909409](https://www.wikidata.org/wiki/Q909409)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/KIT_(gene))  
**Source**: https://4ort.xyz/entity/kit-proto-oncogene-receptor-tyrosine-kinase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL941)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1908391)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2103851)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL482968)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1278146)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL124660)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1642)
10. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P10721)
11. Q20641742
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10721&geneProductId=UniProtKB:P10721)
14. [Mechanism of activation of human c-KIT kinase by internal tandem duplications of the juxtamembrane domain and point mutations at aspartic acid 816](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10721&geneProductId=UniProtKB:P10721)
15. [Mechanism of activation of human c-KIT kinase by internal tandem duplications of the juxtamembrane domain and point mutations at aspartic acid 816](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
16. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
17. [The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
18. [Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
19. [The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
20. [Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
21. [The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
22. [Inhibition of SH2 domain/phosphoprotein association by a nonhydrolyzable phosphonopeptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
23. [Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
24. [Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
25. [Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
26. [Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10721&geneProductId=UniProtKB:P10721)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
29. [Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
30. [Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
31. [Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
32. [Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
33. [CD72 negatively regulates KIT-mediated responses in human mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
34. [Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
35. [Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
36. [Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10721&geneProductId=UniProtKB:P10721)
37. [Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10721&geneProductId=UniProtKB:P10721)
38. [Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
39. [Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10721)
40. Ensembl Release 99
41. UMLS 2023
42. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)