# KIT proto-oncogene receptor tyrosine kinase

> mammalian protein found in Mus musculus

**Wikidata**: [Q21987135](https://www.wikidata.org/wiki/Q21987135)  
**Source**: https://4ort.xyz/entity/kit-proto-oncogene-receptor-tyrosine-kinase-q21987135


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P05532)
3. Q20641742
4. [Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05532&geneProductId=UniProtKB:P05532)
7. [The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
8. [The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
9. [The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
10. [Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
11. [Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
12. [CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
13. [Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
14. [Complex interactions in EML cell stimulation by stem cell factor and IL-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
15. [Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05532&geneProductId=UniProtKB:P05532)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
18. [Ascl1 (Mash1) Knockout Perturbs Differentiation of Nonneuronal Cells in Olfactory Epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
19. [Loss of flk-2/flt3 expression during commitment of multipotent mouse hematopoietic progenitor cells to the mast cell lineage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
20. [Characterization of Definitive Lymphohematopoietic Stem Cells in the Day 9 Murine Yolk Sac](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
21. [Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
22. [A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
23. [Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
24. [GATA-3 is required for early T lineage progenitor development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
25. [Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
26. [miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
27. [Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
28. [Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
29. [CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
30. [E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
31. [Stat5 expression is critical for mast cell development and survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
32. [Stat5a is essential for the proliferation and survival of murine mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
33. [Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
34. [Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
35. [Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
36. [Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
37. [Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05532&geneProductId=UniProtKB:P05532)
38. [Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
39. [Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
40. [Effects of G-protein mutations on skin color](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
41. [Cooperative and indispensable roles of endothelin 3 and KIT signalings in melanocyte development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
42. [Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
43. [Membrane‐bound Kit ligand regulates melanocyte adhesion and survival, providing physical interaction with an intraepithelial niche](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
44. [Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05532&geneProductId=UniProtKB:P05532)
45. [The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
46. [Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
47. [A protective role of mast cells in intestinal tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
48. [c-kit is required for cardiomyocyte terminal differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
49. [Identification of a novel point mutation of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea mutagenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)
50. [A mutation in the Kit gene leads to novel gonadal phenotypes in both heterozygous and homozygous mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05532)