# kinase insert domain receptor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21172390](https://www.wikidata.org/wiki/Q21172390)  
**Source**: https://4ort.xyz/entity/kinase-insert-domain-receptor-q21172390


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL502835)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545365)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545396)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL377300)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2010872)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL558752)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL253969)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL482968)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1278146)
12. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3039525)
13. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2220486)
14. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL274654)
15. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL406381)
16. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P35968)
17. Q20641742
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
19. [Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
20. [Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
21. [Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
22. [Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
23. [AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
24. [The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
25. [Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
26. [Early VEGFR2 activation in response to flow is VEGF-dependent and mediated by MMP activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
27. [Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
28. [VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
29. [VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
30. [The neurotransmitter dopamine modulates vascular permeability in the endothelium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
31. [A role for VEGF as a negative regulator of pericyte function and vessel maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
32. [Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
33. [Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
34. [Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
35. [Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
36. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
37. [New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
38. [Structure of a VEGF-VEGF receptor complex determined by electron microscopy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
39. [Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
40. [Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
41. [Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
42. [Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
43. [The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
44. [Structural determinants of growth factor binding and specificity by VEGF receptor 2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
45. [Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
46. [Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
47. [A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
48. [Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
49. [Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)
50. [Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968)